syncollin Antibody (A-7): sc-376810
- syncollin Antibody (A-7) is a mouse monoclonal IgG1 κ syncollin antibody provided at 200 µg/ml
- raised against amino acids 1-134 representing full length syncollin of human origin
- syncollin Antibody (A-7) is recommended for detection of syncollin of human origin by WB, IP, IF and ELISA
- Anti-syncollin Antibody (A-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG1 BP-HRP is the preferred secondary detection reagent for syncollin Antibody (A-7) for WB applications. This reagent is now offered in a bundle with syncollin Antibody (A-7) (see ordering information below).
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SEE ALSO...
Syncollin Antibody (A-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects syncollin protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-syncollin antibody (A-7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Syncollin (SYCN), also referred to as SYL or insulin synthesis-associated protein 1, is a 134 amino acid protein predominantly expressed in pancreatic acinar cells, where SYCN localizes to secretory vesicle membranes and peripheral membrane lumenal sides. Such localization is crucial as SYCN plays a significant role in exocytosis, influencing zymogen maturation and concentration within zymogen granules, which are essential for proper digestive enzyme secretion. SYCN genes reside on human chromosome 19, a region known for high gene density, housing approximately 1,400 genes, including several immunoglobulin superfamily members vital for immune response and cell signaling.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
syncollin Antibody (A-7) References:
- C-CAM1, a candidate tumor suppressor gene, is abnormally expressed in primary lung cancers. | Wang, L., et al. 2000. Clin Cancer Res. 6: 2988-93. PMID: 10955775
- The genomic context of natural killer receptor extended gene families. | Trowsdale, J., et al. 2001. Immunol Rev. 181: 20-38. PMID: 11513141
- Loss of the zymogen granule protein syncollin affects pancreatic protein synthesis and transport but not secretion. | Antonin, W., et al. 2002. Mol Cell Biol. 22: 1545-54. PMID: 11839820
- Comparative human-mouse-rat sequence analysis of the ICAM gene cluster on HSA 19p13.2 and a 185-kb porcine region from SSC 2q. | Leeb, T. and Müller, M. 2004. Gene. 343: 239-44. PMID: 15588578
- The extended human leukocyte receptor complex: diverse ways of modulating immune responses. | Barrow, AD. and Trowsdale, J. 2008. Immunol Rev. 224: 98-123. PMID: 18759923
- The pregnancy-specific glycoprotein (PSG) gene cluster on human chromosome 19: fine structure of the 11 PSG genes and identification of 6 new genes forming a third subgroup within the carcinoembryonic antigen (CEA) family. | Teglund, S., et al. 1994. Genomics. 23: 669-84. PMID: 7851896
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
syncollin Antibody (A-7) | sc-376810 | 200 µg/ml | $322.00 | |||
syncollin Antibody (A-7): m-IgG1 BP-HRP Bundle | sc-531723 | 200 µg Ab; 20 µg BP | $361.00 | |||
syncollin Antibody (A-7) AC | sc-376810 AC | 500 µg/ml, 25% agarose | $424.00 | |||
syncollin Antibody (A-7) HRP | sc-376810 HRP | 200 µg/ml | $322.00 | |||
syncollin Antibody (A-7) FITC | sc-376810 FITC | 200 µg/ml | $336.00 | |||
syncollin Antibody (A-7) PE | sc-376810 PE | 200 µg/ml | $349.00 | |||
syncollin Antibody (A-7) Alexa Fluor® 488 | sc-376810 AF488 | 200 µg/ml | $364.00 | |||
syncollin Antibody (A-7) Alexa Fluor® 546 | sc-376810 AF546 | 200 µg/ml | $364.00 | |||
syncollin Antibody (A-7) Alexa Fluor® 594 | sc-376810 AF594 | 200 µg/ml | $364.00 | |||
syncollin Antibody (A-7) Alexa Fluor® 647 | sc-376810 AF647 | 200 µg/ml | $364.00 | |||
syncollin Antibody (A-7) Alexa Fluor® 680 | sc-376810 AF680 | 200 µg/ml | $364.00 | |||
syncollin Antibody (A-7) Alexa Fluor® 790 | sc-376810 AF790 | 200 µg/ml | $364.00 |