Date published: 2025-11-24

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Synaptotagmin VII Antibody (4H4): sc-293343

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  • Synaptotagmin VII Antibody (4H4) is a mouse monoclonal IgG2a κ Synaptotagmin VII antibody, cited in 4 publications, provided at 100 µg/ml
  • raised against amino acids 41-139 of Synaptotagmin VII of human origin
  • recommended for detection of Synaptotagmin VII of mouse, rat and human origin by WB, IP and ELISA
  • At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Synaptotagmin VII Antibody (4H4). This work is in progress.

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Synaptotagmin VII Antibody (4H4) is a mouse monoclonal IgG2a kappa light chain antibody that detects Synaptotagmin VII protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-Synaptotagmin VII antibody (4H4) is available as a non-conjugated format. Synaptotagmin VII is a member of the synaptotagmin family, consisting of integral membrane proteins crucial for regulating synaptic vesicle trafficking and neurotransmitter release. Synaptotagmin VII primarily resides in the cytoplasm and associates with synaptic vesicles, functioning as a calcium sensor to facilitate vesicle fusion with plasma membrane during exocytosis. Synaptotagmin VII responds to calcium influx, enabling rapid neurotransmitter release in response to neuronal signals. Synaptotagmin VII′s interaction with proteins like SNAREs ensures precise timing and regulation of neurotransmitter release, making Synaptotagmin VII essential for synaptic transmission and plasticity. Research on Synaptotagmin VII′s function and localization helps illuminate its role in neurological processes and potential involvement in neurodegenerative diseases.

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA

LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences

Synaptotagmin VII Antibody (4H4) References:

  1. Analysis of synaptotagmin I-IV messenger RNA expression and developmental regulation in the rat hypothalamus and pituitary.  |  Xi, D., et al. 1999. Neuroscience. 88: 425-35. PMID: 10197764
  2. The subcellular localizations of atypical synaptotagmins III and VI. Synaptotagmin III is enriched in synapses and synaptic plasma membranes but not in synaptic vesicles.  |  Butz, S., et al. 1999. J Biol Chem. 274: 18290-6. PMID: 10373432
  3. A novel alternatively spliced variant of synaptotagmin VI lacking a transmembrane domain. Implications for distinct functions of the two isoforms.  |  Fukuda, M. and Mikoshiba, K. 1999. J Biol Chem. 274: 31428-34. PMID: 10531344
  4. The human synaptotagmin IV gene defines an evolutionary break point between syntenic mouse and human chromosome regions but retains ligand inducibility and tissue specificity.  |  Ferguson, GD., et al. 2000. J Biol Chem. 275: 36920-6. PMID: 10938284
  5. SNARE complex assembly is required for human sperm acrosome reaction.  |  Tomes, CN., et al. 2002. Dev Biol. 243: 326-38. PMID: 11884041
  6. Protein kinase C-mediated phosphorylation of the two polybasic regions of synaptotagmin VI regulates their function in acrosomal exocytosis.  |  Roggero, CM., et al. 2005. Dev Biol. 285: 422-35. PMID: 16111671
  7. PTP1B dephosphorylates N-ethylmaleimide-sensitive factor and elicits SNARE complex disassembly during human sperm exocytosis.  |  Zarelli, VE., et al. 2009. J Biol Chem. 284: 10491-503. PMID: 19208619
  8. [Comprehensive care as clinical teaching model prepared for general practice].  |  Boyer, G. 1979. J Dent Que. 16: 25-32. PMID: 293343
  9. Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins.  |  Li, C., et al. 1995. Nature. 375: 594-9. PMID: 7791877
  10. A third synaptotagmin gene, Syt3, in the mouse.  |  Hilbush, BS. and Morgan, JI. 1994. Proc Natl Acad Sci U S A. 91: 8195-9. PMID: 8058779
  11. Inositol 1,3,4,5-tetrakisphosphate binding activities of neuronal and non-neuronal synaptotagmins. Identification of conserved amino acid substitutions that abolish inositol 1,3,4,5-tetrakisphosphate binding to synaptotagmins III, V, and X.  |  Ibata, K., et al. 1998. J Biol Chem. 273: 12267-73. PMID: 9575177
  12. Expression of synaptotagmin VIII in rat kidney.  |  Kishore, BK., et al. 1998. Am J Physiol. 275: F131-42. PMID: 9689015

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Synaptotagmin VII Antibody (4H4)

sc-293343
100 µg/ml
$316.00

For Western Blot, is it recommended to use denatured or non-denatured conditions with Synaptotagmin VII (4H4): sc-293343 antibody?

Asked by: DefinitelyNotMatt
Thank you for your question. We recommend this antibody for use in denatured Western Blot conditions. It has not been validated for use in non-denatured conditions. Please contact our Technical Service Department for further details or inquiries.
Answered by: Technical Support
Date published: 2017-03-27
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Rated 5 out of 5 by from Good for Western BlotAntibody detects human recombinant Synaptotagmin VII fusion protein by Western Blot. -SCBT QC
Date published: 2023-09-14
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Synaptotagmin VII Antibody (4H4) is rated 5.0 out of 5 by 1.
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