Synaptotagmin IV Antibody (H-4): sc-271936
- Synaptotagmin IV Antibody (H-4) is a mouse monoclonal IgG1 κ Synaptotagmin IV antibody provided at 200 µg/ml
- raised against amino acids 51-190 mapping within an internal region of Synaptotagmin IV of human origin
- Synaptotagmin IV Antibody (H-4) is recommended for detection of Synaptotagmin IV of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-Synaptotagmin IV Antibody (H-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG1 BP-HRP is the preferred secondary detection reagent for Synaptotagmin IV Antibody (H-4) for WB applications. This reagent is now offered in a bundle with Synaptotagmin IV Antibody (H-4) (see ordering information below).
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Synaptotagmin IV Antibody (H-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects Synaptotagmin IV of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-Synaptotagmin IV antibody (H-4) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Synaptotagmin IV is a member of the synaptotagmin family, which consists of integral membrane proteins that play crucial roles in regulating exocytosis and endocytosis, particularly in neurotransmitter release from synaptic vesicles. Synaptotagmin IV is predominantly expressed in neuronal tissues, with highest mRNA levels found in the hippocampus, an area critical for learning and memory. Synaptotagmin IV localization in the presynaptic terminal is vital for function, acting as a calcium sensor that triggers neurotransmitter release upon calcium influx, thereby facilitating synaptic transmission. Additionally, Synaptotagmin IV gene proximity to markers associated with various psychiatric disorders suggests potential involvement in human diseases, making Synaptotagmin IV a significant target for research in neurobiology and mental health. Synaptotagmin IV (H-4) antibody is an essential tool for studying synaptic transmission dynamics and molecular mechanisms underlying synaptic plasticity.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Synaptotagmin IV Antibody (H-4) References:
- Analysis of synaptotagmin I-IV messenger RNA expression and developmental regulation in the rat hypothalamus and pituitary. | Xi, D., et al. 1999. Neuroscience. 88: 425-35. PMID: 10197764
- The human synaptotagmin IV gene defines an evolutionary break point between syntenic mouse and human chromosome regions but retains ligand inducibility and tissue specificity. | Ferguson, GD., et al. 2000. J Biol Chem. 275: 36920-6. PMID: 10938284
- Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins. | Li, C., et al. 1995. Nature. 375: 594-9. PMID: 7791877
- A third synaptotagmin gene, Syt3, in the mouse. | Hilbush, BS. and Morgan, JI. 1994. Proc Natl Acad Sci U S A. 91: 8195-9. PMID: 8058779
- Expression of synaptotagmin VIII in rat kidney. | Kishore, BK., et al. 1998. Am J Physiol. 275: F131-42. PMID: 9689015
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Synaptotagmin IV Antibody (H-4) | sc-271936 | 200 µg/ml | $316.00 | |||
Synaptotagmin IV Antibody (H-4): m-IgG1 BP-HRP Bundle | sc-531695 | 200 µg Ab; 20 µg BP | $354.00 | |||
Synaptotagmin IV Antibody (H-4) AC | sc-271936 AC | 500 µg/ml, 25% agarose | $416.00 | |||
Synaptotagmin IV Antibody (H-4) HRP | sc-271936 HRP | 200 µg/ml | $316.00 | |||
Synaptotagmin IV Antibody (H-4) FITC | sc-271936 FITC | 200 µg/ml | $330.00 | |||
Synaptotagmin IV Antibody (H-4) PE | sc-271936 PE | 200 µg/ml | $343.00 | |||
Synaptotagmin IV Antibody (H-4) Alexa Fluor® 488 | sc-271936 AF488 | 200 µg/ml | $357.00 | |||
Synaptotagmin IV Antibody (H-4) Alexa Fluor® 546 | sc-271936 AF546 | 200 µg/ml | $357.00 | |||
Synaptotagmin IV Antibody (H-4) Alexa Fluor® 594 | sc-271936 AF594 | 200 µg/ml | $357.00 | |||
Synaptotagmin IV Antibody (H-4) Alexa Fluor® 647 | sc-271936 AF647 | 200 µg/ml | $357.00 | |||
Synaptotagmin IV Antibody (H-4) Alexa Fluor® 680 | sc-271936 AF680 | 200 µg/ml | $357.00 | |||
Synaptotagmin IV Antibody (H-4) Alexa Fluor® 790 | sc-271936 AF790 | 200 µg/ml | $357.00 |