Synaptojanin 1 Antibody (26): sc-136087
- Synaptojanin 1 Antibody (26) is a mouse monoclonal IgG1 provided at 50 µg/0.5 ml
- raised against amino acids 1145-1259 of Synaptojanin 1 of rat origin
- recommended for detection of Synaptojanin 1 of mouse and rat origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Synaptojanin 1 Antibody (26). This work is in progress.
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Synaptojanin 1 Antibody (26) is a mouse monoclonal IgG1 antibody that detects synaptojanin 1 in mouse and rat samples through western blotting (WB) and immunoprecipitation (IP) applications. Synaptojanin 1 is a crucial protein involved in the endocytosis of synaptic vesicles, playing a significant role in neurotransmitter release and synaptic plasticity, which are essential for proper neuronal communication and function. Anti-synaptojanin 1 antibody (26) recognizes two major forms: a shorter variant predominantly found in the brain and a longer variant expressed in peripheral tissues. The presence of synaptojanin 1 in the brain underscores its importance in synaptic function and the regulation of the actin cytoskeleton, which is vital for maintaining the structural integrity of neurons and facilitating the dynamic processes of synaptic transmission. Synaptojanin 1 interacts with various proteins involved in synaptic vesicle trafficking, further highlighting its role in the complex signaling pathways that govern neuronal activity. Anti-synaptojanin 1 antibody (26) serves as an invaluable tool for researchers studying synaptic mechanisms and related neurological disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Synaptojanin 1 Antibody (26) References:
- Synaptojanin 1 contributes to maintaining the stability of GABAergic transmission in primary cultures of cortical neurons. | Luthi, A., et al. 2001. J Neurosci. 21: 9101-11. PMID: 11717343
- Synaptojanin 2 functions at an early step of clathrin-mediated endocytosis. | Rusk, N., et al. 2003. Curr Biol. 13: 659-63. PMID: 12699622
- Regulation of postsynaptic AMPA responses by synaptojanin 1. | Gong, LW. and De Camilli, P. 2008. Proc Natl Acad Sci U S A. 105: 17561-6. PMID: 18987319
- Reduction of synaptojanin 1 accelerates Aβ clearance and attenuates cognitive deterioration in an Alzheimer mouse model. | Zhu, L., et al. 2013. J Biol Chem. 288: 32050-63. PMID: 24052255
- Novel compound heterozygous synaptojanin-1 mutation causes l-dopa-responsive dystonia-parkinsonism syndrome. | Rauschendorf, MA., et al. 2017. Mov Disord. 32: 478-480. PMID: 27869329
- Excess Synaptojanin 1 Contributes to Place Cell Dysfunction and Memory Deficits in the Aging Hippocampus in Three Types of Alzheimer's Disease. | Miranda, AM., et al. 2018. Cell Rep. 23: 2967-2975. PMID: 29874583
- Synaptojanin and Endophilin Mediate Neck Formation during Ultrafast Endocytosis. | Watanabe, S., et al. 2018. Neuron. 98: 1184-1197.e6. PMID: 29953872
- Absence of Sac2/INPP5F enhances the phenotype of a Parkinson's disease mutation of synaptojanin 1. | Cao, M., et al. 2020. Proc Natl Acad Sci U S A. 117: 12428-12434. PMID: 32424101
- Phosphoglycerate kinase is a central leverage point in Parkinson's Disease driven neuronal metabolic deficits. | Kokotos, AC., et al. 2023. bioRxiv.. PMID: 37873141
- Diverse Functions of Parkin in Midbrain Dopaminergic Neurons. | Song, P. and Krainc, D. 2024. Mov Disord. 39: 1282-1288. PMID: 38858837
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Synaptojanin 1 Antibody (26) | sc-136087 | 50 µg/0.5 ml | $322.00 |