You may not log in without verifying your email address.
Please check your email (including your spam email) for the Welcome message that was sent.
Syk Inhibitor IV, BAY 61-3606 (BAY 61-3606) is a cell-permeable imidazopyrimidine compound that acts as a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (Ki = 7.5 nM) with no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src. BAY 61-3606 has been shown to inhibit Syk-mediated cellular functions such as inhibition of high glucose-tyrosine phosphorylation of I κ B α and p65 nuclear translocation. In mast cells BAY 61-3606 has inhibited cytokine synthesis, lipid mediation and degranulation. In addition, monocyte and eosinophil activation by B cells and Fc receptors were suppressed by BAY 61-3606.
1. Yamamoto, N., et al. 2003. J. Pharm. Exp. Ther. 306:1174-1181. PMID: 12766258
2. Yang, W.S., et al. 2008. Am. J. Physiol. Renal Physiol. 294: F1065-F1075. PMID: 18353872
See how others have used Syk Inhibitor IV, BAY 61-3606 HCl. Click on the entry to view the PubMed entry .
PMID: # 28949404 Unsal, D.|Kacan, M.|Temiz-Resitoglu, M.|Guden, DS.|Korkmaz, B.|Sari, AN.|Buharalioglu, CK.|Yildirim-Yaroglu, H.|Tamer-Gumus, L.|Tunctan, B.|Malik, KU.|Sahan-Firat, S.| et al. 2018. Clin. Exp. Pharmacol. Physiol. 45: 155-165.
PMID: # 30104977 Ji, N.|Pan, S.|Shao, C.|Chen, Y.|Zhang, Z.|Wang, R.|Qiu, Y.|Jin, M.|Kong, D.| et al. 2018. Front Pharmacol. 9: 824.
PMID: # 29901140 Qiao, Y. et al. 2018. Mol Med Rep. 18: 1995-2008.
PMID: # 26619766 Vandenbriele, C. et al. 2016. Platelets. 27: 365-72.
PMID: # 26456627 Li, X.|Kwon, O.|Kim, DY.|Taketomi, Y.|Murakami, M.|Chang, HW.| et al. 2016. Allergy. 71: 198-209.
PMID: # 25543269 Kremlitzka, M. et al. 2015. Cellular and molecular life sciences : CMLS. 72: 2223-36.
PMID: # 25917838 Li, X. et al. 2015. Journal of ethnopharmacology. 169: 138-44.
PMID: # 26032420 Callaway, JB. et al. 2015. The Journal of biological chemistry. 290: 17306-20.
PMID: # 24612525 Correale, J. et al. 2014. Journal of neuroimmunology. 269: 76-86.
PMID: # 25484046 Swisher, JF. et al. 2014. mAbs. 6: 1377-84.
Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2020 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.