Syk Inhibitor IV, BAY 61-3606 HCl (CAS 732983-37-8)

Syk Inhibitor IV, BAY 61-3606 HCl, is a chemical compound engineered to selectively block the activity of spleen tyrosine kinase (Syk), a enzyme in the signaling pathways of immune cells. The incorporation of hydrochloride (HCl) enhances its stability and solubility, rendering it more suitable for research purposes. This inhibitor is extensively used in the fields of immunology and oncology for experimental investigations. It plays a vital role in examining Syk kinase′s involvement in immune cell signaling, aiding in the understanding of inflammation, immune cell engagement, and the mechanics of antibody responses. Furthermore, its utility extends to oncology research, where its capacity to impede Syk′s role in cell growth and survival is being assessed for its potential to obstruct tumor development. The efficacy of Syk Inhibitor IV, BAY 61-3606 HCl lies in its targeted disruption of the ATP-binding site on Syk kinase, thereby halting the enzyme′s ability to phosphorylate target substrates and affecting signaling pathways in immune activation and possibly in cancer cell proliferation.