Syk Inhibitor II CAS: 227449-73-2
MF: C14H15F3N6O•2HCl•2H2O
A cell-permeable pyrimidine-carboxamide compound that acts as a potent, selective, and ATP-competitive inhibitor of Syk (IC50 = 41 nM).

Syk Inhibitor II (CAS 227449-73-2)

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Application: A cell-permeable pyrimidine-carboxamide compound that acts as a potent, selective, and ATP-competitive inhibitor of Syk (IC50 = 41 nM)
CAS Number: 227449-73-2
Molecular Weight: 449.26
Molecular Formula: C14H15F3N6O•2HCl•2H2O
* Refer to Certificate of Analysis for lot specific data (including water content).
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Syk Inhibitor II, a cell-permeable pyrimidine-carboxamide compound that acts as a potent, selective, and ATP-competitive inhibitor of Syk (IC50 = 41 nM), while affecting PKCe, PKCbII, ZAP-70, Btk, and Itk only at much higher concentrations (IC50 = 5.1, 11, 11.2, 15.5, and 22.6μM, respectively). Inhibits FceRI-mediated 5-HT release in RBL-2H3 cells in vitro (IC50 = 460 nM) and passive cutaneous anaphylaxis (PCA) reaction in mice in vivo (ID50 = 13.2 mg/kg, s.c.).


References

Hisamichi, H., et al. 2005. Bioorg. Med. Chem. 13, 4936.

Physical State :
Solid
Solubility :
Soluble in water (25 mg/ml), and DMSO (100 mg/ml).
Storage :
Store at 4° C
Refractive Index :
n20D ~1.63 (Predicted)
IC50 :
Syk: IC50 = 41 nM; PKCε: IC50 = 5.1 µM; PKCβII: IC50 = 11 µM; ZAP-70: IC50 = 11.2 µM; Btk: IC50 = 15.5 µM; Itk: IC50 = 22.6 µM; FcεRI-mediated 5-HT release: IC50 = 460 nM (RBL-2H3 cells); Lysyl-tRNA synthetase: IC50 = 41 nM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
16760670
SMILES :
C1=CC(=CC(=C1)NC2=NC(=NC=C2C(=O)N)NCCN)C(F)(F)F.O.O.Cl.Cl

Download SDS (MSDS)

Certificate of Analysis

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