Molecular structure of Syk Inhibitor II, CAS Number: 227449-73-2
Syk Inhibitor II (CAS 227449-73-2)
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Application:
Syk Inhibitor II is a cell-permeable pyrimidine-carboxamide compound that acts as a potent, selective, and ATP-competitive inhibitor of Syk (IC50 = 41 nM)
CAS Number:
227449-73-2
Molecular Weight:
449.26
Molecular Formula:
C14H15F3N6O•2HCl•2H2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Syk Inhibitor II, a cell-permeable pyrimidine-carboxamide compound that acts as a potent, selective, and ATP-competitive inhibitor of Syk (IC50 = 41 nM), while affecting PKCe, PKCbII, ZAP-70, Btk, and Itk only at much higher concentrations (IC50 = 5.1, 11, 11.2, 15.5, and 22.6μM, respectively). Inhibits FceRI-mediated 5-HT release in RBL-2H3 cells in vitro (IC50 = 460 nM) and passive cutaneous anaphylaxis (PCA) reaction in mice in vivo (ID50 = 13.2 mg/kg, s.c.).
Inhibitor of:
Syk, and Tyrosine Kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Syk Inhibitor II, 1 mg | sc-281683 | 1 mg | $500.00 |