Molecular structure of Syk Inhibitor, CAS Number: 622387-85-3
Syk Inhibitor Inhibitor (CAS 622387-85-3)
See product citations (1)
Application:
Syk Inhibitor is an inhibitor of FcεRI-mediated degranulation in RBL-2H3
CAS Number:
622387-85-3
Purity:
≥97%
Molecular Weight:
353.4
Molecular Formula:
C18H15N3O3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Syk Inhibitor is an oxindole compound that acts to effectively inhibit FcepsilonRI-mediated degranulation in RBL-2H3. Syk Inhibitor is an inhibitor of Syk. 3-MIMS exhibits notable properties such as anti-inflammatory, antiplatelet, and antifungal activities.
Syk Inhibitor Inhibitor (CAS 622387-85-3) References
- Potent small molecule inhibitors of spleen tyrosine kinase (Syk). | Lai, JY., et al. 2003. Bioorg Med Chem Lett. 13: 3111-4. PMID: 12941345
- A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery. | Gao, Y., et al. 2013. Biochem J. 451: 313-28. PMID: 23398362
- A split-luciferase complementation, real-time reporting assay enables monitoring of the disease-associated transmembrane protein TREM2 in live cells. | Varnum, MM., et al. 2017. J Biol Chem. 292: 10651-10663. PMID: 28490631
- High-throughput screening and bioinformatic analysis to ascertain compounds that prevent saturated fatty acid-induced β-cell apoptosis. | Lee, SH., et al. 2017. Biochem Pharmacol. 138: 140-149. PMID: 28522407
- THP-1 cells increase TNF-α production upon LPS + soluble human IgG co-stimulation supporting evidence for TLR4 and Fcγ receptors crosstalk. | Vargas-Hernández, O., et al. 2020. Cell Immunol. 355: 104146. PMID: 32702524
- Complementary roles of platelet αIIbβ3 integrin, phosphatidylserine exposure and cytoskeletal rearrangement in the release of extracellular vesicles. | Heinzmann, ACA., et al. 2020. Atherosclerosis. 310: 17-25. PMID: 32877806
- Gain-of-function variants in SYK cause immune dysregulation and systemic inflammation in humans and mice. | Wang, L., et al. 2021. Nat Genet. 53: 500-510. PMID: 33782605
Inhibitor of:
PTPRCAP, and Syk.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Syk Inhibitor, 5 mg | sc-204316 | 5 mg | $218.00 |