Swiprosin-2 Antibody (S-33): sc-100684
- Swiprosin-2 Antibody (S-33) is a mouse monoclonal IgG2a κ Swiprosin-2 antibody provided at 100 µg/ml
- raised against recombinant Swiprosin-2 of human origin
- recommended for detection of Swiprosin-2 of mouse, rat and human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Swiprosin-2 Antibody (S-33). This work is in progress.
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Swiprosin-2 Antibody (S-33) is a mouse monoclonal IgG2a kappa light chain antibody that detects Swiprosin-2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-Swiprosin-2 antibody (S-33) is available as a non-conjugated format. Swiprosin-2, also known as EFHD1 (EF-hand domain-containing protein D1), SWS2, PP3051, or MST133, is a 239 amino acid protein characterized by the presence of two EF-hand domains, which are critical for calcium ion binding. These EF-hand domains form a stable four-helix bundle structure that facilitates the binding of calcium ions, a process essential for various cellular functions, including signal transduction and muscle contraction. Swiprosin-2′s ability to bind calcium suggests a potential role as a calcium sensor, particularly in neuronal differentiation, where expression is upregulated, indicating importance in brain development and maturation. This makes Swiprosin-2 a significant protein for studying neurobiology and related disorders.
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Swiprosin-2 Antibody (S-33) References:
- Novel genes cloned from a neuronal cell line newly established from a cerebellum of an adult p53(-/-) mouse. | Tominaga, M. and Tomooka, Y. 2002. Biochem Biophys Res Commun. 297: 473-9. PMID: 12270117
- HNF4alpha reduces proliferation of kidney cells and affects genes deregulated in renal cell carcinoma. | Lucas, B., et al. 2005. Oncogene. 24: 6418-31. PMID: 16007190
- Structures and metal-ion-binding properties of the Ca2+-binding helix-loop-helix EF-hand motifs. | Gifford, JL., et al. 2007. Biochem J. 405: 199-221. PMID: 17590154
- Essential dynamics of helices provide a functional classification of EF-hand proteins. | Capozzi, F., et al. 2007. J Proteome Res. 6: 4245-55. PMID: 17935310
- HNF4 alpha orchestrates a set of 14 genes to down-regulate cell proliferation in kidney cells. | Grigo, K., et al. 2008. Biol Chem. 389: 179-87. PMID: 18163890
- Free-energy linkage between folding and calcium binding in EF-hand proteins. | Suarez, MC., et al. 2008. Biophys J. 95: 4820-8. PMID: 18689462
- Drosophila Swiprosin-1/EFHD2 accumulates at the prefusion complex stage during Drosophila myoblast fusion. | Hornbruch-Freitag, C., et al. 2011. J Cell Sci. 124: 3266-78. PMID: 21896648
- Structural and Biochemical Characterization of EFhd1/Swiprosin-2, an Actin-Binding Protein in Mitochondria. | Mun, SA., et al. 2020. Front Cell Dev Biol. 8: 628222. PMID: 33537316
- EFHD1 ablation inhibits cardiac mitoflash activation and protects cardiomyocytes from ischemia. | Eberhardt, DR., et al. 2022. J Mol Cell Cardiol. 167: 1-14. PMID: 35304170
- EFHD1, a novel mitochondrial regulator of tumor metastasis in clear cell renal cell carcinoma. | Meng, K., et al. 2023. Cancer Sci. 114: 2029-2040. PMID: 36747492
- EFHD1 expression is correlated with tumor-infiltrating neutrophils and predicts prognosis in gastric cancer. | Zhao, B., et al. 2023. Heliyon. 9: e21062. PMID: 37876466
- EFHD1 promotes osteosarcoma proliferation and drug resistance by inhibiting the opening of the mitochondrial membrane permeability transition pore (mPTP) by binding to ANT3. | Shen, X., et al. 2024. Cell Mol Life Sci. 81: 236. PMID: 38795203
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Swiprosin-2 Antibody (S-33) | sc-100684 | 100 µg/ml | $333.00 |