Date published: 2025-10-31

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(−)-Sweroside (CAS 14215-86-2)

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CAS Number:
14215-86-2
Molecular Weight:
358.34
Molecular Formula:
C16H22O9
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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(−)-Sweroside is a secoiridoid glycoside that belongs to the class of monoterpenes. It features a glucose moiety bonded to a cyclic monoterpene core, making it valuable for studying plant secondary metabolites and their biosynthetic pathways. As a significant constituent of the Gentianaceae family, (−)-sweroside has been researched extensively in the context of plant biochemistry to explain its role in plant defense mechanisms. Its glycoside structure is ideal for investigating glycosyl hydrolase activities, specifically the enzymes involved in cleaving glycosidic bonds to release the aglycone, sweroside. In phytochemical research, (−)-sweroside aids in identifying the unique metabolite profiles of medicinal plants. It is often used as a marker compound in the quality control and standardization of botanical extracts. The molecule′s inherent bioactivity has prompted extensive investigation into its role in plant signaling and interaction with herbivores. Additionally, it serves as a precursor in the biosynthesis of more complex iridoids and secoiridoids, offering insights into the enzymatic pathways involved. Researchers use (−)-sweroside to study the structural and functional diversity of plant-derived glycosides and their ecological significance. Overall, (−)-sweroside provides a window into understanding the complex chemical ecology and metabolism of plant natural products.


(−)-Sweroside (CAS 14215-86-2) References

  1. Sweroside Alleviated LPS-Induced Inflammation via SIRT1 Mediating NF-κB and FOXO1 Signaling Pathways in RAW264.7 Cells.  |  Wang, R., et al. 2019. Molecules. 24: PMID: 30823686
  2. Sweroside ameliorated carbon tetrachloride (CCl4)-induced liver fibrosis through FXR-miR-29a signaling pathway.  |  Gong, J., et al. 2020. J Nat Med. 74: 17-25. PMID: 31280460
  3. Sweroside promotes osteoblastic differentiation and mineralization via interaction of membrane estrogen receptor-α and GPR30 mediated p38 signalling pathway on MC3T3-E1 cells.  |  Wu, QC., et al. 2020. Phytomedicine. 68: 153146. PMID: 32028183
  4. Sweroside Prevents Non-Alcoholic Steatohepatitis by Suppressing Activation of the NLRP3 Inflammasome.  |  Yang, G., et al. 2020. Int J Mol Sci. 21: PMID: 32316419
  5. Sweroside Protects Against Myocardial Ischemia-Reperfusion Injury by Inhibiting Oxidative Stress and Pyroptosis Partially via Modulation of the Keap1/Nrf2 Axis.  |  Li, J., et al. 2021. Front Cardiovasc Med. 8: 650368. PMID: 33816579
  6. Anti-inflammatory Effects of Sweroside on LPS-Induced ALI in Mice Via Activating SIRT1.  |  Wang, J., et al. 2021. Inflammation. 44: 1961-1968. PMID: 33913051
  7. Sweroside Ameliorated Memory Deficits in Scopolamine-Induced Zebrafish (Danio rerio) Model: Involvement of Cholinergic System and Brain Oxidative Stress.  |  Brinza, I., et al. 2022. Molecules. 27: PMID: 36144637
  8. Sweroside alleviates hepatic steatosis in part by activating AMPK/mTOR-mediated autophagy in mice.  |  Ding, Y., et al. 2023. J Cell Biochem. 124: 1012-1022. PMID: 37269482
  9. Sweroside attenuates podocyte injury and proteinuria in part by activating Akt/BAD signaling in mice.  |  Huang, M., et al. 2023. J Cell Biochem. 124: 1749-1763. PMID: 37796169
  10. Sweroside plays a role in mitigating high glucose-induced damage in human renal tubular epithelial HK-2 cells by regulating the SIRT1/NF-κB signaling pathway.  |  Ma, X., et al. 2023. Korean J Physiol Pharmacol. 27: 533-540. PMID: 37884285

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

(−)-Sweroside, 10 mg

sc-474490
10 mg
$380.00