SV40 T Ag Antibody (PAb419): sc-58665
- SV40 T Ag Antibody (PAb419) is a mouse monoclonal IgG2a κ, cited in 13 publications, provided at 200 µg/ml
- raised against full length T antigen of SV40 origin
- recommended for detection of N-terminal domain of large and small T antigen of SV40 origin by WB, IP, IF and ELISA
- See SV40 T Ag (Pab 101): sc-147 for SV40 T Ag antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for SV40 T Ag Antibody (PAb419) for WB applications. These reagents are now offered in bundles with SV40 T Ag Antibody (PAb419) (see ordering information below).
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SEE ALSO...
SV40 T Ag Antibody (PAb419) is a mouse monoclonal IgG2a antibody that detects SV40 T antigen of SV40 species reactivity by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-SV40 T antigen antibody (PAb419) plays a crucial role in cancer research, as SV40 T antigen is a key player in viral transformation of host cells. SV40 T antigen is primarily located in the nucleus, where SV40 T antigen exerts effects by interacting with critical cellular proteins such as tumor suppressor p53 and retinoblastoma protein (Rb). Nuclear localization of SV40 T antigen is essential for function, as this positioning allows disruption of normal cell cycle regulation and promotion of uncontrolled cell proliferation. Through binding to p53, SV40 T antigen inhibits tumor-suppressive functions, while interaction with Rb prevents Rb-E2F complex from regulating transcription of genes necessary for cell cycle progression. Understanding mechanisms by which SV40 T antigen manipulates cellular pathways is vital for developing therapeutic strategies against cancers associated with viral infections.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SV40 T Ag Antibody (PAb419) | sc-58665 | 200 µg/ml | $322.00 | |||
SV40 T Ag Antibody (PAb419): m-IgG Fc BP-HRP Bundle | sc-539091 | 200 µg Ab; 10 µg BP | $361.00 | |||
SV40 T Ag Antibody (PAb419): m-IgG2a BP-HRP Bundle | sc-546668 | 200 µg Ab; 10 µg BP | $361.00 |