Molecular structure of Supercinnamaldehyde, CAS Number: 70351-51-8
Supercinnamaldehyde (CAS 70351-51-8)
Alternate Names:
1,3-Dihydro-1-methyl-3-(2-oxopropylidene)-2H-Indol-2-one; Cinnamic aldehyde
Application:
Supercinnamaldehyde is a transient receptor potential ANKTM1 (ankyrin 1 (TRPA1)) activator
CAS Number:
70351-51-8
Purity:
≥98%
Molecular Weight:
201.22
Molecular Formula:
C12H11NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Supercinnamaldehyde is a transient receptor potential ankyrin 1 (TRPA1) activator, EC50 = 0.8 µM, derivative of cinnamaldehyde, covalently binds to and activates TRPA1 receptor (expressed in nociceptive neurons) by modifying its cysteine residues. Covalent modification of reactive cysteines within TRPA1 can cause channel activation, and rapid signaling potential tissue damage through the pain pathway.
Supercinnamaldehyde (CAS 70351-51-8) References
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- Vasodilatory effects of cinnamaldehyde and its mechanism of action in the rat aorta. | Xue, YL., et al. 2011. Vasc Health Risk Manag. 7: 273-80. PMID: 21603596
- Functional expression of TRPV1 and TRPA1 in rat vestibular ganglia. | Kamakura, T., et al. 2013. Neurosci Lett. 552: 92-7. PMID: 23916509
- Indolin-2-one compounds targeting thioredoxin reductase as potential anticancer drug leads. | Kaminska, KK., et al. 2016. Oncotarget. 7: 40233-40251. PMID: 27244886
- Protective effects of cinnamon bark extract against ischemia-reperfusion injury and arrhythmias in rat. | Sedighi, M., et al. 2018. Phytother Res. 32: 1983-1991. PMID: 29917280
- Cinnamaldehyde ameliorates STZ-induced rat diabetes through modulation of IRS1/PI3K/AKT2 pathway and AGEs/RAGE interaction. | Abdelmageed, ME., et al. 2019. Naunyn Schmiedebergs Arch Pharmacol. 392: 243-258. PMID: 30460386
- Neuro-amelioration of cinnamaldehyde in aluminum-induced Alzheimer's disease rat model. | Mustafa, HN. 2020. J Histotechnol. 43: 11-20. PMID: 31460853
- Cinnamaldehyde protects against rat intestinal ischemia/reperfusion injuries by synergistic inhibition of NF-κB and p53. | Almoiliqy, M., et al. 2020. Acta Pharmacol Sin. 41: 1208-1222. PMID: 32238887
- Network pharmacology-based research uncovers cold resistance and thermogenesis mechanism of Cinnamomum cassia. | Xiang-Li, ., et al. 2021. Fitoterapia. 149: 104824. PMID: 33388379
- Neuroprotective Effect of Cinnamaldehyde on Secondary Brain Injury After Traumatic Brain Injury in a Rat Model. | Kuru Bektaşoğlu, P., et al. 2021. World Neurosurg. 153: e392-e402. PMID: 34224887
- Cinnamaldehyde treatment during adolescence improves white and brown adipose tissue metabolism in a male rat model of early obesity. | Neto, JGO., et al. 2022. Food Funct. 13: 3405-3418. PMID: 35230374
- Cinnamaldehyde attenuates kidney senescence and injury through PI3K/Akt pathway-mediated autophagy via downregulating miR-155. | Xiao, Q. 2022. Ren Fail. 44: 601-614. PMID: 35361048
- Improved uptake and bioavailability of cinnamaldehyde via solid lipid nanoparticles for oral delivery. | Wu, L., et al. 2022. Pharm Dev Technol. 27: 1038-1048. PMID: 36367964
- Cinnamaldehyde Supplementation Reverts Endothelial Dysfunction in Rat Models of Diet-Induced Obesity: Role of NF-E2-Related Factor-2. | Sena, CM., et al. 2022. Antioxidants (Basel). 12: PMID: 36670944
Activator of:
ANKTM1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Supercinnamaldehyde, 5 mg | sc-253616 | 5 mg | $81.00 |