Super-DHB (CAS 63542-76-7)
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Super-DHB is a substance suitable as a matrix substance for MALDI-MS that is comprised of a 9:1 mixture of DHB and 2-hydroxy-5-methoxybenzoic acid. The 2-hydroxy-5-methoxybenzoic acid additive′s beneficial effect is ascribed to inducing disorder in the 2,5-DHB crystal lattice, leading to improved ion desorption with reduced internal energy, resulting in minimized metastable fragmentation. Researchers have observed an increase in sensitivity of up to 2 to 3-fold in a standard dextran mixture, alongside enhanced resolution due to reduced metastable ion formation. Moreover, the Super-DHB matrix has shown promise in generating enhanced signals from tryptic glycopeptides. Notably, its usage has been reported to decrease matrix background ions, resulting in glycan signals exhibiting improved signal-to-noise ratios and higher resolution in the mass spectrum.
Super-DHB (CAS 63542-76-7) References
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Super-DHB, 1 g | sc-236958 | 1 g | $102.00 |