Date published: 2025-10-2

1-800-457-3801

SCBT Portrait Logo
Seach Input

Sunitinib, Free Base (CAS 557795-19-4)

0.0(0)
Write a reviewAsk a question

See product citations (5)

Alternate Names:
Sutent; sunitinibum
Application:
Sunitinib, Free Base is an inhibitor of receptor tyrosine kinases
CAS Number:
557795-19-4
Purity:
≥99%
Molecular Weight:
398.47
Molecular Formula:
C22H27FN4O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

Sunitinib, Free Base is a small molecule that is used extensively in various research applications, particularly those related to its role as a multi-targeted receptor tyrosine kinase (RTK) inhibitor. In research environments, it is employed to study signal transduction pathways involved in cell proliferation and angiogenesis. Sunitinib, Free Base is valuable for in vitro experiments aiming to understand the molecular mechanisms of action of RTK inhibitors and their effects on tumor growth and metastasis. It is also a subject of interest in the field of cancer biology, where it is used to investigate the cellular responses to kinase inhibition, including apoptosis, cell cycle arrest, and the impact on the tumor microenvironment. Moreover, Sunitinib, Free Base serves as a tool compound in studies focusing on the resistance mechanisms that can emerge following RTK inhibition. Additionally, it is used in chemical biology to explore the off-target effects of kinase inhibitors and to dissect complex signaling networks within cells.


Sunitinib, Free Base (CAS 557795-19-4) References

  1. The pharmacokinetic interaction between irinotecan and sunitinib.  |  Jiang, L., et al. 2020. Cancer Chemother Pharmacol. 85: 443-448. PMID: 31691077
  2. Sunitinib-associated hyperammonemic encephalopathy.  |  Lipe, DN., et al. 2021. Am J Emerg Med. 46: 282-283. PMID: 32811710
  3. Synergizing sunitinib and radiofrequency ablation to treat hepatocellular cancer by triggering the antitumor immune response.  |  Qi, X., et al. 2020. J Immunother Cancer. 8: PMID: 33115942
  4. Tyrosine Kinase Inhibitor Sunitinib Delays Platelet-Induced Coagulation: Additive Effects of Aspirin.  |  Tullemans, BME., et al. 2022. Thromb Haemost. 122: 92-104. PMID: 34130349
  5. Key sunitinib-related biomarkers for renal cell carcinoma.  |  Peng, Y., et al. 2021. Cancer Med. 10: 6917-6930. PMID: 34402193
  6. Autophagic degradation of CCN2 (cellular communication network factor 2) causes cardiotoxicity of sunitinib.  |  Xu, Z., et al. 2022. Autophagy. 18: 1152-1173. PMID: 34432562
  7. Sunitinib-Induced Hypothyroidism and Survival in Pancreatic Neuroendocrine Tumors.  |  Mathew, A., et al. 2021. Horm Metab Res. 53: 794-800. PMID: 34891209
  8. Metformin Protects Against Sunitinib-induced Cardiotoxicity: Investigating the Role of AMPK.  |  Kuburas, R., et al. 2022. J Cardiovasc Pharmacol. 79: 799-807. PMID: 35266920
  9. Elevated SNRPA1, as a Promising Predictor Reflecting Severe Clinical Outcome via Effecting Tumor Immunity for ccRCC, Is Related to Cell Invasion, Metastasis, and Sunitinib Sensitivity.  |  Jiang, A., et al. 2022. Front Immunol. 13: 842069. PMID: 35281041
  10. Sunitinib potentiates the cytotoxic effect of electrochemotherapy in pancreatic carcinoma cells.  |  Bosnjak, M., et al. 2022. Radiol Oncol. 56: 164-172. PMID: 35344644
  11. Role of Sam68 in Sunitinib induced renal cell carcinoma apoptosis.  |  Wu, Z., et al. 2022. Cancer Med. 11: 3674-3686. PMID: 35476809
  12. Necroptosis modulation by cisplatin and sunitinib in hepatocellular carcinoma cell line.  |  El-Demiry, SM., et al. 2022. Life Sci. 301: 120594. PMID: 35500680
  13. Sunitinib-Induced Elevation of Mean Corpuscular Volume (MCV)-Exploring Its Possible Clinical Relevance in Cancer Patients.  |  Rihacek, M., et al. 2022. Curr Oncol. 29: 4138-4147. PMID: 35735439
  14. Sunitinib-Induced Congestive Heart Failure in a Patient with Gastrointestinal Stromal Tumor.  |  Ben Kridis, W., et al. 2022. Arch Iran Med. 25: 399-401. PMID: 35943020

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Sunitinib, Free Base, 500 mg

sc-396319
500 mg
$150.00

Sunitinib, Free Base, 5 g

sc-396319A
5 g
$920.00