Molecular structure of Sumatriptan succinate, CAS Number: 103628-48-4
Sumatriptan succinate (CAS 103628-48-4)
Alternate Names:
Micralgin; Migratan
Application:
Sumatriptan succinate is a selective 5-HT1 receptor agonist
CAS Number:
103628-48-4
Purity:
≥98%
Molecular Weight:
413.49
Molecular Formula:
C14H21N3O2S•C4H6O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Sumatriptan succinate is a selective 5-HT1 receptor agonist with specificity towards SR-1D (5-HT1D), SR-1B (5-HT1B) and SR-1A (5-HT1A). In addition, the physicochemical properties of Sumatriptan succinate can be characterized using FT-IR, HPLC, SEM and XRD. It has been reported that Sumatriptan succinate can be produced via reactive precipitation without the presence of surfactants. Further studies show that molecules of Sumatriptan succinate are carried through cells using liposomes, with positively charged liposomes exhibiting the highest loading efficiency.
Sumatriptan succinate (CAS 103628-48-4) References
- Comparative study of a combination of isometheptene mucate, dichloralphenazone with acetaminophen and sumatriptan succinate in the treatment of migraine. | Freitag, FG., et al. 2001. Headache. 41: 391-8. PMID: 11318886
- Determination of degradation products of sumatriptan succinate using LC-MS and LC-MS-MS. | Xu, X., et al. 2001. J Pharm Biomed Anal. 26: 367-77. PMID: 11489382
- Development and validation of an LC assay for sumatriptan succinate residues on surfaces in the manufacture of pharmaceuticals. | Nozal, MJ., et al. 2002. J Pharm Biomed Anal. 30: 285-91. PMID: 12191714
- Effect of chemical enhancers on the in vitro percutaneous absorption of sumatriptan succinate. | Femenía-Font, A., et al. 2005. Eur J Pharm Biopharm. 61: 50-5. PMID: 15925502
- In vitro and in vivo evaluation of the transdermal iontophoretic delivery of sumatriptan succinate. | Patel, SR., et al. 2007. Eur J Pharm Biopharm. 66: 296-301. PMID: 17182233
- Production of ultrafine sumatriptan succinate particles for pulmonary delivery. | Yang, ZY., et al. 2008. Pharm Res. 25: 2012-8. PMID: 18581210
- Mucoadhesive bilayered patches for administration of sumatriptan succinate. | Shidhaye, SS., et al. 2008. AAPS PharmSciTech. 9: 909-16. PMID: 18679806
- Formulation and evaluation of nasal mucoadhesive microspheres of sumatriptan succinate. | Jain, SA., et al. 2009. J Microencapsul. 26: 711-21. PMID: 19888880
- Positively and negatively charged liposomes as carriers for transdermal delivery of sumatriptan: in vitro characterization. | Villasmil-Sánchez, S., et al. 2010. Drug Dev Ind Pharm. 36: 666-75. PMID: 20136486
- Elastic vesicles of sumatriptan succinate for transdermal administration: characterization and in vitro permeation studies. | Balaguer-Fernández, C., et al. 2011. J Liposome Res. 21: 55-9. PMID: 20429812
- Formulation and optimization of orally disintegrating tablets of sumatriptan succinate. | Sheshala, R., et al. 2011. Chem Pharm Bull (Tokyo). 59: 920-8. PMID: 21804234
- Formulation and evaluation of bucco-adhesive tablets of sumatriptan succinate. | Prasanna, RI., et al. 2011. Int J Pharm Investig. 1: 182-91. PMID: 23071941
- Formulation and evaluation of sublingual tablets containing Sumatriptan succinate. | Prajapati, ST., et al. 2012. Int J Pharm Investig. 2: 162-8. PMID: 23373008
- Sumatriptan succinate loaded chitosan solid lipid nanoparticles for enhanced anti-migraine potential. | Hansraj, GP., et al. 2015. Int J Biol Macromol. 81: 467-76. PMID: 26299709
- Dissolving polyvinylpyrrolidone-based microneedle systems for in-vitro delivery of sumatriptan succinate. | Ronnander, P., et al. 2018. Eur J Pharm Sci. 114: 84-92. PMID: 29203152
Activator of:
SR-1A, SR-1B, and SR-1D.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Sumatriptan succinate, 1 g | sc-204314 | 1 g | $92.00 | |||
Sumatriptan succinate, 5 g | sc-204314A | 5 g | $349.00 |