SULT1A1 Antibody (214E2Z): sc-517645
- SULT1A1 Antibody (214E2Z) is a mouse monoclonal IgG1 κ SULT1A1 antibody provided at 100 µg/ml
- raised against recombinant SULT1A1 of human origin
- recommended for detection of SULT1A1 of mouse, rat and human origin by WB
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for SULT1A1 Antibody (214E2Z). This work is in progress.
SULT1A1 Antibody (214E2Z) is a mouse monoclonal IgG1 kappa light chain antibody that detects SULT1A1 protein of mouse, rat, and human origin by western blotting (WB). Anti-SULT1A1 antibody (214E2Z) is available as a non-conjugated format. SULT1A1, also known as sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1, is a crucial enzyme that plays a significant role in the metabolism of various endogenous and exogenous compounds. This 295 amino acid protein primarily localizes in the cytoplasm and functions as a homodimer, exhibiting expression in key tissues such as the brain, liver, skin, and lung. SULT1A1 is essential for the sulfate conjugation of catecholamines, phenolic drugs, and neurotransmitters, facilitating their elimination from the body. SULT1A1 is also implicated in the activation of carcinogenic N-hydroxyarylamines, highlighting potential involvement in carcinogenesis. Selective activity of SULT1A1 within the sulfotransferase superfamily underscores importance in drug metabolism and detoxification processes, making SULT1A1 a valuable target for research in pharmacology and toxicology.
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SULT1A1 Antibody (214E2Z) References:
- Association between functional genetic polymorphisms of human sulfotransferases 1A1 and 1A2. | Engelke, CE., et al. 2000. Pharmacogenetics. 10: 163-9. PMID: 10762004
- Sulfotransferases in the bioactivation of xenobiotics. | Glatt, H. 2000. Chem Biol Interact. 129: 141-70. PMID: 11154739
- CYP1A1, SULT1A1, and SULT1E1 polymorphisms are risk factors for endometrial cancer susceptibility. | Hirata, H., et al. 2008. Cancer. 112: 1964-73. PMID: 18318428
- Interaction of the cytochrome P4501A2, SULT1A1 and NAT gene polymorphisms with smoking and dietary mutagen intake in modification of the risk of pancreatic cancer. | Suzuki, H., et al. 2008. Carcinogenesis. 29: 1184-91. PMID: 18499698
- Case-control study and meta-analysis of SULT1A1 Arg213His polymorphism for gene, ethnicity and environment interaction for cancer risk. | Kotnis, A., et al. 2008. Br J Cancer. 99: 1340-7. PMID: 18854828
- Sulfotransferase 1A1 haplotypes associated with oral squamous cell carcinoma susceptibility in male Taiwanese. | Chung, YT., et al. 2009. Carcinogenesis. 30: 286-94. PMID: 19126640
- An investigation of the relationship between SULT1A1 Arg(213)His polymorphism and lung cancer susceptibility in a Turkish population. | Arslan, S., et al. 2009. Cell Biochem Funct. 27: 211-5. PMID: 19350537
- Structural similarity and diversity of sulfotransferases. | Yamazoe, Y., et al. 1994. Chem Biol Interact. 92: 107-17. PMID: 8033246
- Genomic organization and DNA sequences of two human phenol sulfotransferase genes (STP1 and STP2) on the short arm of chromosome 16. | Dooley, TP. and Huang, Z. 1996. Biochem Biophys Res Commun. 228: 134-40. PMID: 8912648
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SULT1A1 Antibody (214E2Z) | sc-517645 | 100 µg/ml | $322.00 |