Sulochrin (CAS 519-57-3)
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Sulochrin, a synthetic compound, serves as an artificial molecule effectively inhibiting various enzymes, including those involved in fatty acid and protein synthesis. Its versatile nature has led to its extensive utilization in a diverse range of research applications. Notably, it has served as useful in comprehending the role of protein synthesis in cellular function. Additionally, Sulochrin′s effects on reactive oxygen species production and immune cell activity modulation have been investigated. The inhibitory action of Sulochrin specifically targets acyl-CoA synthetase, an enzyme for the conversion of fatty acids into acyl-CoA. By inhibiting this enzyme, Sulochrin effectively hinders fatty acid synthesis. Furthermore, Sulochrin inhibits phospholipase A2, which facilitates the release of fatty acids from cell membranes.
Sulochrin (CAS 519-57-3) References
- Effects of ortho-substituent groups of sulochrin on inhibitory activity to eosinophil degranulation. | Ohashi, H., et al. 1999. Bioorg Med Chem Lett. 9: 1945-8. PMID: 10450959
- Fungal metabolites, asterric acid derivatives inhibit vascular endothelial growth factor (VEGF)-induced tube formation of HUVECs. | Lee, HJ., et al. 2002. J Antibiot (Tokyo). 55: 552-6. PMID: 12195960
- Rational elimination of Aspergillus terreus sulochrin production. | Couch, RD. and Gaucher, GM. 2004. J Biotechnol. 108: 171-8. PMID: 15129726
- Physiological, morphological and kinetic aspects of lovastatin biosynthesis by Aspergillus terreus. | Bizukojc, M. and Ledakowicz, S. 2009. Biotechnol J. 4: 647-64. PMID: 19452466
- Specific inhibition of hepatitis C virus entry into host hepatocytes by fungi-derived sulochrin and its derivatives. | Nakajima, S., et al. 2013. Biochem Biophys Res Commun. 440: 515-20. PMID: 24099774
- Bioactive sulfur-containing sulochrin dimers and other metabolites from an Alternaria sp. isolate from a Hawaiian soil sample. | Cai, S., et al. 2014. J Nat Prod. 77: 2280-7. PMID: 25265160
- The effect of viscosity, friction, and sonication on the morphology and metabolite production from Aspergillus terreus ATCC 20542. | Rahim, MHA., et al. 2017. Bioprocess Biosyst Eng. 40: 1753-1761. PMID: 28879627
- Polyketides from the marine-derived fungus Aspergillus falconensis: In silico and in vitro cytotoxicity studies. | El-Kashef, DH., et al. 2021. Bioorg Med Chem. 29: 115883. PMID: 33248353
- p-Terphenyls as Anti-HSV-1/2 Agents from a Deep-Sea-Derived Penicillium sp. | Chen, W., et al. 2021. J Nat Prod. 84: 2822-2831. PMID: 34766503
- Sulochrins and alkaloids from a fennel endophyte Aspergillus sp. FVL2. | Shaaban, M., et al. 2023. Nat Prod Res. 37: 1310-1320. PMID: 34865573
- Manipulation of the Global Regulator mcrA Upregulates Secondary Metabolite Production in Aspergillus wentii Using CRISPR-Cas9 with In Vitro Assembled Ribonucleoproteins. | Yuan, B., et al. 2022. ACS Chem Biol. 17: 2828-2835. PMID: 36197945
- Sulochrin inhibits eosinophil degranulation. | Ohashi, H., et al. 1997. J Antibiot (Tokyo). 50: 972-4. PMID: 9592574
- Sulochrin inhibits eosinophil activation and chemotaxis. | Ohashi, H., et al. 1998. Inflamm Res. 47: 409-15. PMID: 9831326
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Sulochrin, 1 mg | sc-202349 | 1 mg | $193.00 |