Date published: 2026-2-13

1-800-457-3801

SCBT Portrait Logo
Seach Input

sulfo-NHS-acetate (CAS 152305-87-8)

0.0(0)
Write a reviewAsk a question

See product citations (1)

Alternate Names:
Sulfosuccinimidyl acetate
CAS Number:
152305-87-8
Molecular Weight:
259.17
Molecular Formula:
C6H6NO7S•Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

Sulfo-NHS-acetate is a compound utilized in the field of bioconjugation chemistry for the modification of proteins and other biomolecules. Its functional groups allow it to act as a bridge between amine groups and other reactive moieties, facilitating the covalent attachment of various labels or tags to target molecules. In research applications, sulfo-NHS-acetate is used to study the surface properties of proteins, enabling scientists to track their interactions and functions. The sulfonate group enhances the compound′s solubility in water, which is particularly advantageous for reactions in physiological conditions. Additionally, sulfo-NHS-acetate is instrumental in the preparation of affinity matrices for use in purification protocols, where it helps immobilize ligands onto solid supports.


sulfo-NHS-acetate (CAS 152305-87-8) References

  1. Topography of the surface of the Escherichia coli phosphotransferase system protein enzyme IIAglc that interacts with lactose permease.  |  Sondej, M., et al. 2000. Biochemistry. 39: 2931-9. PMID: 10715113
  2. ET(B) receptor activation causes exocytic insertion of NHE3 in OKP cells.  |  Peng, Y., et al. 2001. Am J Physiol Renal Physiol. 280: F34-42. PMID: 11133512
  3. Molecular stability of chemically modified collagen triple helices.  |  Giudici, C., et al. 2003. FEBS Lett. 547: 170-6. PMID: 12860408
  4. Probing rhodopsin-transducin interactions by surface modification and mass spectrometry.  |  Wang, X., et al. 2004. Biochemistry. 43: 11153-62. PMID: 15366925
  5. Glucocorticoids acutely increase cell surface Na+/H+ exchanger-3 (NHE3) by activation of NHE3 exocytosis.  |  Bobulescu, IA., et al. 2005. Am J Physiol Renal Physiol. 289: F685-91. PMID: 15942046
  6. Revealing a positive charge patch on a recombinant monoclonal antibody by chemical labeling and mass spectrometry.  |  Zhang, L., et al. 2011. Anal Chem. 83: 8501-8. PMID: 22004540
  7. Solution versus gas-phase modification of peptide cations with NHS-ester reagents.  |  Mentinova, M., et al. 2012. J Am Soc Mass Spectrom. 23: 282-9. PMID: 22081458
  8. Reagent cluster anions for multiple gas-phase covalent modifications of peptide and protein cations.  |  Prentice, BM., et al. 2013. J Am Soc Mass Spectrom. 24: 1045-52. PMID: 23702708
  9. Monoclonal antibody fragment removal mediated by mixed mode resins.  |  O'Connor, E., et al. 2017. J Chromatogr A. 1499: 65-77. PMID: 28389094
  10. Gas-Phase Ion/Ion Chemistry for Structurally Sensitive Probes of Gaseous Protein Ion Structure: Electrostatic and Electrostatic to Covalent Cross-Linking.  |  Kit, MCS., et al. 2021. Int J Mass Spectrom. 463: PMID: 33716558
  11. LRP1 is a neuronal receptor for α-synuclein uptake and spread.  |  Chen, K., et al. 2022. Mol Neurodegener. 17: 57. PMID: 36056345

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

sulfo-NHS-acetate, 100 mg

sc-472023
100 mg
$143.00