Sulfathiazole sodium salt (CAS 144-74-1)

Sulfathiazole sodium salt, a derivative of sulfonamide, has been extensively studied in scientific research for its antimicrobial properties and its role in combating bacterial infections. This compound functions by competitively inhibiting the enzyme dihydropteroate synthase, a crucial component of the folate biosynthesis pathway in bacteria. By interfering with folate synthesis, sulfathiazole sodium salt disrupts the production of essential nucleic acids and proteins, ultimately leading to bacterial growth inhibition. Researchers have utilized sulfathiazole sodium salt in various studies investigating bacterial resistance mechanisms, synergistic antibiotic combinations, and novel antimicrobial strategies. Additionally, this compound has been employed as a model system to explore the molecular basis of sulfonamide resistance and to explain structure-activity relationships guiding the development of new antimicrobial agents. Furthermore, sulfathiazole sodium salt has been utilized in microbiological research to study bacterial physiology, pathogenesis, and the mechanisms underlying bacterial susceptibility to antibiotics. Its well-established mechanism of action and broad spectrum of activity make sulfathiazole sodium salt a valuable tool for advancing our understanding of bacterial biology and for developing new approaches to combat antibiotic-resistant infections.