Sulfaquinoxaline sodium salt (CAS 967-80-6)

Sulfaquinoxaline sodium salt is a derivative of quinoxaline and a member of the sulfonamide family, characterized by its distinct molecular structure that includes a quinoxaline ring substituted by a sulfa group. This chemical has been extensively studied in various research settings, particularly for its interesting interactions with bacterial dihydropteroate synthase, an enzyme involved in the folate synthesis pathway. Sulfaquinoxaline acts by inhibiting this enzyme, which is crucial for the production of dihydrofolic acid, a precursor needed for bacterial DNA synthesis. In the context of scientific research, Sulfaquinoxaline sodium salt has been utilized in studies focused on understanding bacterial resistance mechanisms. The research has explored how mutations in the target enzyme or increased production of the enzyme can decrease the efficacy of sulfa, including Sulfaquinoxaline. This has broad implications for the design of new inhibitors that can overcome resistance. Moreover, the compound has been a subject in biochemical studies aiming to explain the detailed interaction between the sulfonamide group and the enzyme. These studies typically involve advanced techniques like X-ray crystallography to visualize the docking and binding efficiencies, as well as kinetic assays to measure the impact of the compound on enzyme activity.