Sulfapyridine-d4 (CAS 1189863-86-2)
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Sulfapyridine-d4 is a compound that functions as a competitive inhibitor of dihydropteroate synthase, an enzyme involved in the folate synthesis pathway in bacteria. By inhibiting this enzyme, Sulfapyridine-d4 disrupts the production of tetrahydrofolic acid, which is for the synthesis of nucleic acids and amino acids in bacteria. This disruption ultimately leads to the inhibition of bacterial growth and proliferation. Sulfapyridine-d4 achieves this by binding to the active site of dihydropteroate synthase, preventing the enzyme from catalyzing the formation of dihydropteroic acid, a precursor in folate synthesis. As a result, the bacteria are unable to produce biomolecules, leading to their eventual demise. This mechanism of action makes Sulfapyridine-d4 useful for studying bacterial folate metabolism and developing strategies to combat bacterial infections.
Sulfapyridine-d4 (CAS 1189863-86-2) References
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- An LC-MS/MS method for the simultaneous quantitation of sulfasalazine and sulfapyridine in human placenta. | Louw, V., et al. 2023. J Pharm Biomed Anal. 235: 115633. PMID: 37597383
- A modified QuEChERS-based UPLC-MS/MS method for rapid determination of multiple antibiotics and sedative residues in freshwater fish. | Yang, Y., et al. 2024. Food Chem X. 22: 101268. PMID: 38495454
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Sulfapyridine-d4, 1 mg | sc-220166 | 1 mg | $454.00 |