Date published: 2025-12-2

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Sulfanilic acid (CAS 121-57-3)

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Alternate Names:
4-Aminobenzenesulfonic acid; p-Anilinesulfonic Acid; 4-Sulfoaniline
Application:
Sulfanilic acid is a Tartrazine metabolite used for detection of nitrites
CAS Number:
121-57-3
Purity:
≥99%
Molecular Weight:
173.19
Molecular Formula:
C6H7NO3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Sulfanilic acid, also known as 4-aminobenzenesulfonic acid, is used as Ehrlich′s reagent for detection of nitrites. It is also a metabolite of Tartrazine. Sulfanilic acid, a synthetic intermediate, finds diverse applications in various fields. Its synthesis involves sulfonation of aniline with sulfuric acid. This synthetic organic compound plays a role in the production of optical brightening agents, synthetic organic dyes, food colorants, and additives. Appearing as a white powder with a faint purple tinge, or grayish-white flat crystals, Sulfanilic Acid becomes anhydrous at approximately 212°F. Furthermore, Sulfanilic acid, a derivative of aniline sulfonated at the para-position, serves multiple functions as a xenobiotic metabolite, a xenobiotic, an environmental contaminant, and an allergen. It acts as the conjugate acid of a 4-aminobenzenesulfonate. With its involvement in the synthesis of activated carbon for biodiesel preparation and various nanocomposites, Sulfanilic acid proves to be a versatile and indispensable compound in various industries.


Sulfanilic acid (CAS 121-57-3) References

  1. Aerobic degradation of sulfanilic acid using activated sludge.  |  Chen, G., et al. 2012. Water Res. 46: 145-51. PMID: 22085771
  2. Electrochemical incineration of sulfanilic acid at a boron-doped diamond anode.  |  El-Ghenymy, A., et al. 2012. Chemosphere. 87: 1126-33. PMID: 22365277
  3. Ammonium-oxidizing bacteria facilitate aerobic degradation of sulfanilic acid in activated sludge.  |  Chen, G., et al. 2014. Water Sci Technol. 70: 1122-8. PMID: 25259503
  4. Complete genome sequence of Novosphingobium resinovorum SA1, a versatile xenobiotic-degrading bacterium capable of utilizing sulfanilic acid.  |  Hegedűs, B., et al. 2017. J Biotechnol. 241: 76-80. PMID: 27851894
  5. Starvation- and xenobiotic-related transcriptomic responses of the sulfanilic acid-degrading bacterium, Novosphingobium resinovorum SA1.  |  Hegedüs, B., et al. 2018. Appl Microbiol Biotechnol. 102: 305-318. PMID: 29051988
  6. Sulfanilic Acid Pending on a Graphene Scaffold: Novel, Efficient Synthesis and Much Enhanced Polymer Solar Cell Efficiency and Stability Using It as a Hole Extraction Layer.  |  Zhao, FG., et al. 2018. ACS Appl Mater Interfaces. 10: 24679-24688. PMID: 29968469
  7. Sulfanilic acid increases intracellular free-calcium concentration, induces reactive oxygen species production and impairs trypsin secretion in pancreatic AR42J cells.  |  Ameur, FZ., et al. 2018. Food Chem Toxicol. 120: 71-80. PMID: 29986830
  8. Effective Removal of Sulfanilic Acid From Water Using a Low-Pressure Electrochemical RuO2-TiO2@Ti/PVDF Composite Membrane.  |  Zheng, J., et al. 2018. Front Chem. 6: 395. PMID: 30238003
  9. Colorimetric detection of the β-agonist ractopamine in animal feed, tissue and urine samples using gold-silver alloy nanoparticles modified with sulfanilic acid.  |  Hu, X., et al. 2019. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 36: 35-45. PMID: 30517825
  10. Specific Non-Reducing Ends in Heparins from Different Animal Origins: Building Blocks Analysis Using Reductive Amination Tagging by Sulfanilic Acid.  |  Mourier, PAJ. 2020. Molecules. 25: PMID: 33256116
  11. Biofouling suppresses effluent toxicity in an electrochemical filtration system for remediation of sulfanilic acid-contaminated water.  |  Tian, C., et al. 2022. Water Res. 219: 118545. PMID: 35550968
  12. Development of In Vitro Evaluation System for Assessing Drug Dissolution Considering Physiological Environment in Nasal Cavity.  |  Inoue, D., et al. 2022. Pharmaceutics. 14: PMID: 36365167

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Sulfanilic acid, 25 g

sc-212977
25 g
$36.00

Sulfanilic acid, 100 g

sc-212977A
100 g
$112.00