Molecular structure of Sulfamethoxazole-d4, CAS Number: 1020719-86-1
Sulfamethoxazole-d4 (CAS 1020719-86-1)
See product citations (4)
Alternate Names:
4-Amino-N-(5-methyl-3-isoxazolyl)(benzene-d4)sulfonamide; 3-(p-Amino(benzene-d4)sulfonamido)-5-methylisoxazole
Application:
Sulfamethoxazole-d4 is an isotopically labeled antibacterial agent
CAS Number:
1020719-86-1
Purity:
98%
Molecular Weight:
257.30
Molecular Formula:
C10H7D4N3O3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Sulfamethoxazole-d4 inhibits the synthesis of dihydrofolic acid by competing with para-aminobenzoic acid (PABA) for binding to dihydropteroate synthetase, an enzyme involved in the folic acid synthesis pathway. This disruption of folate metabolism ultimately leads to the inhibition of bacterial growth and proliferation. Sulfamethoxazole-d4 works with trimethoprim to target both the early and late stages of folic acid synthesis, resulting in a synergistic bactericidal effect. By interfering with the production of necessary metabolites, Sulfamethoxazole-d4 disrupts the cellular processes necessary for bacterial survival, making it an effective antibiotic against a wide range of Gram-positive and Gram-negative bacteria. This inhibition of folate synthesis is particularly for bacteria, as they are unable to take up preformed folic acid from their environment and must synthesize it de novo.
Sulfamethoxazole-d4 (CAS 1020719-86-1) References
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- Formation of diclofenac and sulfamethoxazole reversible transformation products in aquifer material under denitrifying conditions: batch experiments. | Barbieri, M., et al. 2012. Sci Total Environ. 426: 256-63. PMID: 22534360
- Online solid-phase extraction-liquid chromatography-electrospray-tandem mass spectrometry determination of multiple classes of antibiotics in environmental and treated waters. | Panditi, VR., et al. 2013. Anal Bioanal Chem. 405: 5953-64. PMID: 23494277
- Quantification of co-trimoxazole in serum and plasma using MS/MS. | Dijkstra, JA., et al. 2015. Bioanalysis. 7: 2741-9. PMID: 26566213
- Enhanced sulfamethoxazole degradation through ammonia oxidizing bacteria co-metabolism and fate of transformation products. | Kassotaki, E., et al. 2016. Water Res. 94: 111-119. PMID: 26938496
- Identification of the priority antibiotics based on their detection frequency, concentration, and ecological risk in urbanized coastal water. | Li, F., et al. 2020. Sci Total Environ. 747: 141275. PMID: 32777509
- Rapid determination of multi-antibiotic residues in honey based on modified QuEChERS method coupled with UPLC-MS/MS. | Yang, Y., et al. 2022. Food Chem. 374: 131733. PMID: 34875428
- Evaluation of Sample Preparation Methods for Non-Target Screening of Organic Micropollutants in Urban Waters Using High-Resolution Mass Spectrometry. | Huynh, N., et al. 2021. Molecules. 26: PMID: 34885646
- A HPLC-MS/MS method for screening of selected antibiotic adulterants in herbal drugs. | Mwankuna, CJ., et al. 2022. Anal Methods. 14: 1060-1068. PMID: 35195137
- In-situ multi-mode extraction (iMME) sampler for a wide-scope analysis of chemical and biological targets in water in urbanized and remote (off-the-grid) locations. | Sims, N., et al. 2023. Sci Total Environ. 859: 160034. PMID: 36356746
- Occurrence and fate of an emerging drug pollutant and its by-products during conventional and advanced wastewater treatment: Case study of furosemide. | Sandre, F., et al. 2023. Chemosphere. 322: 138212. PMID: 36822517
- Simultaneous extraction of four classes of antibiotics in soil, manure and sewage sludge and analysis by liquid chromatography-tandem mass spectrometry with the isotope-labelled internal standard method | Huang, Y., Cheng, M., Li, W., Wu, L., Chen, Y., Luo, Y.,.. & Zhang, H. 2013. Analytical Methods. 5(15): 3721-3731.
- Determination of Pharmaceuticals Discharged in Wastewater from a Public Hospital Using LC-MS/MS Technique | Hernández-Tenorio, R., Guzmán-Mar, J. L., Hinojosa-Reyes, L., Ramos-Delgado, N., & Hernández-Ramírez, A. 2021. Journal of the Mexican Chemical Society. 65(1): 94-108.
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Enzyme.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Sulfamethoxazole-d4, 5 mg | sc-220161 | 5 mg | $500.00 | |||
Sulfamethoxazole-d4, 25 mg | sc-220161A | 25 mg | $812.00 | |||
Sulfamethoxazole-d4, 50 mg | sc-220161B | 50 mg | $1200.00 | |||
Sulfamethoxazole-d4, 100 mg | sc-220161C | 100 mg | $2000.00 |