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Sulfamethazine sodium salt (CAS 1981-58-4)

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Application:
Sulfamethazine sodium salt is a sulfanilamide antibacterial agent
CAS Number:
1981-58-4
Molecular Weight:
301.31
Molecular Formula:
C12H14N4O2SNa
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Sulfamethazine sodium salt is a compound that functions as a competitive inhibitor of dihydropteroate synthase, an enzyme involved in the folic acid synthesis pathway in bacteria. By inhibiting this enzyme, it disrupts the production of tetrahydrofolic acid, which is essential for the synthesis of nucleic acids and proteins in bacteria. This disruption ultimately leads to the inhibition of bacterial growth and reproduction. Sulfamethazine sodium salt achieves this by acting as a structural analog of para-aminobenzoic acid, which is a substrate for dihydropteroate synthase. As a result, the enzyme mistakenly incorporates the compound into the folic acid synthesis pathway, leading to the inhibition of bacterial growth. This mechanism of action makes sulfamethazine sodium salt may be useful for studying bacterial resistance to antibiotics and for investigating the molecular basis of bacterial folic acid synthesis.


Sulfamethazine sodium salt (CAS 1981-58-4) References

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  2. Novel approach to control sulfamethazine misuse in food-producing animals by hair analysis.  |  Gratacós-Cubarsí, M., et al. 2006. Food Addit Contam. 23: 981-7. PMID: 16982519
  3. Evaluation of three different microbial inhibition tests for the detection of sulphamethazine residues in the edible tissues of rabbit.  |  Kozárová, I., et al. 2009. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 26: 978-87. PMID: 19680973
  4. Complexation of sulfonamides with beta-cyclodextrin studied by experimental and theoretical methods.  |  Zoppi, A., et al. 2010. J Pharm Sci. 99: 3166-76. PMID: 20166198
  5. Magnetic N-doped 3D graphene-like framework carbon for extraction of cephalexin monohydrate and ceftiofur hydrochloride.  |  Niu, P., et al. 2020. Talanta. 215: 120932. PMID: 32312468
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  7. Persistence of the antimicrobials lincomycin, chlortetracycline, and sulfamethazine in prairie wetlands.  |  Cessna, AJ., et al. 2020. J Environ Qual. 49: 236-245. PMID: 33016366
  8. Functionalized Persistent Luminescence Nanoparticle-Based Aptasensor for Autofluorescence-free Determination of Kanamycin in Food Samples.  |  Wang, BB., et al. 2021. Anal Chem. 93: 2589-2595. PMID: 33410662
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Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Sulfamethazine sodium salt, 25 g

sc-251084
25 g
$39.00

Sulfamethazine sodium salt, 100 g

sc-251084A
100 g
$107.00

Sulfamethazine sodium salt, 500 g

sc-251084B
500 g
$490.00

Sulfamethazine sodium salt, 1 kg

sc-251084C
1 kg
$969.00

Sulfamethazine sodium salt, 5 kg

sc-251084D
5 kg
$3060.00

Sulfamethazine sodium salt, 25 kg

sc-251084E
25 kg
$9180.00