Molecular structure of sulfalene, CAS Number: 152-47-6
sulfalene (CAS 152-47-6)
CAS Number:
152-47-6
Purity:
≥98%
Molecular Weight:
280.30
Molecular Formula:
C11H12N4O3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Sulfalene is a chemical compound that functions as a competitive inhibitor of dihydropteroate synthase, an enzyme involved in the folate synthesis pathway in bacteria. By inhibiting this enzyme, sulfalene disrupts the production of tetrahydrofolic acid for the synthesis of nucleic acids and proteins in bacterial cells. This disruption ultimately leads to the inhibition of bacterial growth and reproduction. Sulfalene achieves this by binding to the active site of dihydropteroate synthase, preventing the enzyme from catalyzing the formation of dihydropteroic acid, a precursor in folate synthesis.
sulfalene (CAS 152-47-6) References
- Host failure in treatment of malaria with sulfalene and pyrimethamine. | Trenholme, GM., et al. 1975. Ann Intern Med. 82: 219-23. PMID: 1090224
- Simultaneous quantitative analysis of the antimalarials pyrimethamine and sulfamethoxypyrazine in plasma samples using liquid chromatography/tandem mass spectrometry. | Storme, ML., et al. 2006. Rapid Commun Mass Spectrom. 20: 2947-53. PMID: 16952211
- [Effects of sulfalene on the thymus, spleen and adrenals in an experiment]. | Panchishina, MV., et al. 1991. Antibiot Khimioter. 36: 26-7. PMID: 1793291
- Determination of sulfalene in plasma, red blood cells and whole blood by high-performance liquid chromatography. | Dua, VK., et al. 1991. J Chromatogr. 563: 333-40. PMID: 2055996
- Nitrogen-14 nuclear quadrupole resonance spectroscopy: a promising analytical methodology for medicines authentication and counterfeit antimalarial analysis. | Barras, J., et al. 2013. Anal Chem. 85: 2746-53. PMID: 23384229
- Development of a simple, rapid, and robust liquid chromatographic method for the simultaneous determination of sulfalene, sulfadoxine, and pyrimethamine in tablets. | Mwalwisi, YH., et al. 2016. J Pharm Biomed Anal. 129: 558-570. PMID: 27505128
- [Effect of sulfalene and furosemide on benzylpenicillin kinetics in rats with aseptic inflammation]. | Agapitova, IV. and Iakovlev, VP. 1988. Antibiot Khimioter. 33: 917-21. PMID: 3245708
- [Macrolide antibiotics: characteristics of their interaction with organoids, intracellular distribution and the effect of sulfalene]. | Guliaev, AE. and Kivman, GIa. 1985. Antibiot Med Biotekhnol. 30: 103-6. PMID: 4004182
- Influence of sulfalene upon gametocytogenesis of Plasmodium falciparum and subsequent infection patterns in Anopheles stephensi. | McCarthy, VC. and Clyde, DF. 1973. Exp Parasitol. 33: 73-8. PMID: 4570982
- [Sulfalene pharmacogenetics. II. The population genetic aspect]. | Kholodov, LE., et al. 1979. Genetika. 15: 2210-4. PMID: 510916
- [Sulfalene pharmacogenetics. I. The genetic determination of the pharmacokinetic indices]. | Lil'in, ET., et al. 1979. Genetika. 15: 2204-9. PMID: 574478
- [Pharmacodynamics of cephaloridine and cephalothin combined with sulfalene in rabbits]. | Bobrov, VI., et al. 1984. Antibiotiki. 29: 823-5. PMID: 6524880
- [Pharmacokinetics of sulfalene and sulfamethoxine after combined administration with benzylpenicillin and ampicillin]. | Bobrov, VI., et al. 1984. Antibiotiki. 29: 277-82. PMID: 6742805
- Treatment of falciparum malaria with sulfalene-pyrimethamine versus sulfadoxine-pyrimethamine. | Chongsuphajaisiddhi, T., et al. 1980. Southeast Asian J Trop Med Public Health. 11: 524-7. PMID: 7013094
- [Sulfalene kinetics in the blood and cerebrospinal fluid in arachnoiditis]. | Geĭtman, IIa., et al. 1982. Farmakol Toksikol. 45: 83-5. PMID: 7128796
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
sulfalene, 100 mg | sc-280099 | 100 mg | $133.00 |