Sulfadiazine Silver Salt (CAS 22199-08-2)

Sulfadiazine silver salt, a chemical compound, has been a subject of scientific research due to its antimicrobial properties and unique mechanism of action. This compound combines the antimicrobial effects of both sulfadiazine and silver ions. Sulfadiazine functions as a sulfonamide antibiotic by competitively inhibiting the enzyme dihydropteroate synthase (DHPS) in bacteria, thereby disrupting folate metabolism and inhibiting bacterial growth. The addition of silver ions enhances the antimicrobial activity, as silver ions are known for their broad-spectrum antimicrobial effects by disrupting bacterial cell membranes, inhibiting DNA replication, and inducing oxidative stress. In research settings, sulfadiazine silver salt has been utilized for studying microbial growth inhibition, antimicrobial resistance mechanisms, and the development of novel antimicrobial agents. Moreover, it has been explored for its potential applications in wound dressings, medical devices, and coatings to prevent bacterial colonization and infection. Additionally, research efforts have focused on optimizing its efficacy and safety profile for various research applications, including biomedical and environmental fields.