Sulbutiamine (CAS 3286-46-2)
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Sulbutiamine is a synthetic compound that is a dimeric form of thiamine (vitamin B1). It is primarily studied in the context of nutritional science, where its enhanced lipophilic properties compared to thiamine are of interest for facilitating its crossing of lipid membranes. In biochemical research, Sulbutiamine is examined for its impact on thiamine levels in the brain and its subsequent effects on cognitive function and energy metabolism. Studies also focus on its influence on enzyme systems involved in the Krebs cycle and the pentose phosphate pathway, critical pathways in cellular respiration and glucose metabolism. Additionally, Sulbutiamine is a subject of research in the field of neuroscience, as it is considered in relation to the modulation of neurotransmitter activity, particularly in the cholinergic system. Researchers are also interested in its potential to affect mitochondrial function and neuronal communication, which are key factors in the study of cellular physiology.
Sulbutiamine (CAS 3286-46-2) References
- Potentiometric sensors for the selective determination of sulbutiamine. | Ahmed, MA. and Elbeshlawy, MM. 1999. J Pharm Biomed Anal. 21: 415-21. PMID: 10703998
- Evidence for a modulatory effect of sulbutiamine on glutamatergic and dopaminergic cortical transmissions in the rat brain. | Trovero, F., et al. 2000. Neurosci Lett. 292: 49-53. PMID: 10996447
- Chronic treatment with sulbutiamine improves memory in an object recognition task and reduces some amnesic effects of dizocilpine in a spatial delayed-non-match-to-sample task. | Bizot, JC., et al. 2005. Prog Neuropsychopharmacol Biol Psychiatry. 29: 928-35. PMID: 15951087
- Sulbutiamine, an 'innocent' over the counter drug, interferes with therapeutic outcome of bipolar disorder. | Douzenis, A., et al. 2006. World J Biol Psychiatry. 7: 183-5. PMID: 16861144
- Benfotiamine, a synthetic S-acyl thiamine derivative, has different mechanisms of action and a different pharmacological profile than lipid-soluble thiamine disulfide derivatives. | Volvert, ML., et al. 2008. BMC Pharmacol. 8: 10. PMID: 18549472
- Sulbutiamine counteracts trophic factor deprivation induced apoptotic cell death in transformed retinal ganglion cells. | Kang, KD., et al. 2010. Neurochem Res. 35: 1828-39. PMID: 20809085
- Evidence for neuroprotective effect of sulbutiamine against oxygen-glucose deprivation in rat hippocampal CA1 pyramidal neurons. | Kwag, J., et al. 2011. Biol Pharm Bull. 34: 1759-64. PMID: 22040892
- Sulphur antioxidants inhibit oxidative stress induced retinal ganglion cell death by scavenging reactive oxygen species but influence nuclear factor (erythroid-derived 2)-like 2 signalling pathway differently. | Majid, AS., et al. 2013. Biol Pharm Bull. 36: 1095-110. PMID: 23811559
- Stability-Indicating HPTLC Method for Studying Stress Degradation Behavior of Sulbutiamine HCl. | Farid, NF. and Abdelwahab, NS. 2016. J Chromatogr Sci. 54: 609-17. PMID: 26759487
- Sulbutiamine shows promising results in reducing fatigue in patients with multiple sclerosis. | Sevim, S., et al. 2017. Mult Scler Relat Disord. 16: 40-43. PMID: 28755683
- First characterization of a microsporidial triosephosphate isomerase and the biochemical mechanisms of its inactivation to propose a new druggable target. | García-Torres, I., et al. 2018. Sci Rep. 8: 8591. PMID: 29872223
- Thiamine mimetics sulbutiamine and benfotiamine as a nutraceutical approach to anticancer therapy. | Jonus, HC., et al. 2020. Biomed Pharmacother. 121: 109648. PMID: 31810115
- [On the specific treatment of asthenic states: focus on sulbutiamine]. | Bykov, YV. and Bekker, RA. 2022. Ter Arkh. 94: 689-694. PMID: 36286970
- Chronic administration of sulbutiamine improves long term memory formation in mice: possible cholinergic mediation. | Micheau, J., et al. 1985. Pharmacol Biochem Behav. 23: 195-8. PMID: 4059305
- The compartmentation of phosphorylated thiamine derivatives in cultured neuroblastoma cells. | Bettendorff, L. 1994. Biochim Biophys Acta. 1222: 7-14. PMID: 8186267
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Sulbutiamine, 1 g | sc-394472 | 1 g | $180.00 | |||
Sulbutiamine, 5 g | sc-394472A | 5 g | $260.00 | |||
Sulbutiamine, 10 g | sc-394472B | 10 g | $300.00 | |||
Sulbutiamine, 25 g | sc-394472C | 25 g | $380.00 | |||
Sulbutiamine, 50 g | sc-394472D | 50 g | $430.00 |