SUG1 Antibody (35): sc-136085

SUG1 Antibody (35) is a mouse monoclonal IgG1 antibody that detects SUG1 in mouse, rat, human, and canine samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). SUG1, also known as PSMC5, p45, or S8, is a crucial ATPase subunit of the 26S proteasome complex, which plays a vital role in the regulated degradation of ubiquitinated proteins, thereby maintaining cellular homeostasis. SUG1 is primarily localized in the cytoplasm and nucleus, where SUG1 is integral to the 19S regulatory particle of the proteasome, facilitating the recognition and processing of substrates, particularly those associated with the endoplasmic reticulum. SUG1′s importance extends beyond its structural role; recent research indicates that SUG1 phosphorylation by specific protein kinases is essential for the assembly of the 26S proteasome, highlighting a regulatory mechanism that could influence proteasome activity and, consequently, protein turnover within the cell. Furthermore, SUG1 has been shown to interact with key transcription factors such as the retinoid X receptor and thyroid hormone receptor, suggesting a significant role in modulating gene expression in response to hormonal signals. With multifaceted functions, SUG1 is a critical component in both proteolytic processes and transcriptional regulation, making anti-SUG1 antibody (35) an invaluable tool for researchers studying these pathways.

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SUG1 Antibody (35) References:

1. Phosphorylation by p38MAPK and recruitment of SUG-1 are required for RA-induced RAR gamma degradation and transactivation.  |  Giannì, M., et al. 2002. EMBO J. 21: 3760-9. PMID: 12110588
2. Mouse homologue of yeast Prp19 interacts with mouse SUG1, the regulatory subunit of 26S proteasome.  |  Sihn, CR., et al. 2007. Biochem Biophys Res Commun. 356: 175-80. PMID: 17349974
3. Regulation of acetylation at the major histocompatibility complex class II proximal promoter by the 19S proteasomal ATPase Sug1.  |  Koues, OI., et al. 2008. Mol Cell Biol. 28: 5837-50. PMID: 18662994
4. SUG-1 plays proteolytic and non-proteolytic roles in the control of retinoic acid target genes via its interaction with SRC-3.  |  Ferry, C., et al. 2009. J Biol Chem. 284: 8127-35. PMID: 19144644
5. Mammalian Sug1 and c-Fos in the nuclear 26S proteasome.  |  Wang, W., et al. 1996. Proc Natl Acad Sci U S A. 93: 8236-40. PMID: 8710853
6. The XPB subunit of repair/transcription factor TFIIH directly interacts with SUG1, a subunit of the 26S proteasome and putative transcription factor.  |  Weeda, G., et al. 1997. Nucleic Acids Res. 25: 2274-83. PMID: 9173976
7. Identification of a phylogenetically conserved Sug1 CAD family member that is differentially expressed in the mouse nervous system.  |  Sun, D., et al. 1997. J Neurobiol. 33: 877-90. PMID: 9407011
8. Phosducin-like protein (PhLP), a regulator of G beta gamma function, interacts with the proteasomal protein SUG1.  |  Barhite, S., et al. 1998. Biochim Biophys Acta. 1402: 95-101. PMID: 9551090
9. Proteasome-mediated degradation of the vitamin D receptor (VDR) and a putative role for SUG1 interaction with the AF-2 domain of VDR.  |  Masuyama, H. and MacDonald, PN. 1998. J Cell Biochem. 71: 429-40. PMID: 9831079
10. Adenovirus early region 1A protein binds to mammalian SUG1-a regulatory component of the proteasome.  |  Grand, RJ., et al. 1999. Oncogene. 18: 449-58. PMID: 9927201

The preferred SUG1 antibody is SUG1 Antibody (H-7): sc-390631.