SUG1 Antibody (2837C4a): sc-81388

SUG1 Antibody (2837C4a) is a mouse monoclonal IgG1 antibody that detects SUG1 in mouse, rat, and human samples through applications such as western blotting (WB) and immunoprecipitation (IP). SUG1, also known as PSMC5, is a crucial ATPase subunit of the 26S proteasome complex, which plays a vital role in the regulated degradation of ubiquitinated proteins, thereby maintaining cellular homeostasis. SUG1 (2837C4a) antibody targets a protein primarily localized in the cytoplasm and nucleus, where SUG1 is integral to the 19S regulatory particle of the proteasome, facilitating the recognition and processing of substrates, particularly those involved in the endoplasmic reticulum-associated degradation pathway. SUG1′s importance extends beyond its structural role; recent research indicates that SUG1 phosphorylation by specific protein kinases is essential for the assembly of the 26S proteasome, highlighting a regulatory mechanism that could influence proteasome activity and, consequently, protein turnover within the cell. Additionally, SUG1 has been shown to interact with key transcription factors such as the retinoid X receptor and thyroid hormone receptor, suggesting a significant role in modulating gene expression in response to hormonal signals. With these multifaceted functions in both proteostasis and transcriptional regulation, anti-SUG1 antibody (2837C4a) serves as an invaluable tool for researchers studying these processes.

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SUG1 Antibody (2837C4a) References:

1. Human Sug1/p45 is involved in the proteasome-dependent degradation of Sp1.  |  Su, K., et al. 2000. Biochem J. 348 Pt 2: 281-9. PMID: 10816420
2. MYO18B interacts with the proteasomal subunit Sug1 and is degraded by the ubiquitin-proteasome pathway.  |  Inoue, T., et al. 2006. Biochem Biophys Res Commun. 342: 829-34. PMID: 16499872
3. The 19S proteasome ATPase Sug1 plays a critical role in regulating MHC class II transcription.  |  Bhat, KP., et al. 2008. Mol Immunol. 45: 2214-24. PMID: 18215421
4. Interaction with Sug1 enables Ipaf ubiquitination leading to caspase 8 activation and cell death.  |  Kumar, Y., et al. 2010. Biochem J. 427: 91-104. PMID: 20085538
5. Role of Sug1, a 19S proteasome ATPase, in the transcription of MHC I and the atypical MHC II molecules, HLA-DM and HLA-DO.  |  Inostroza-Nieves, Y., et al. 2012. Immunol Lett. 147: 67-74. PMID: 22771340
6. A Disease-associated Mutant of NLRC4 Shows Enhanced Interaction with SUG1 Leading to Constitutive FADD-dependent Caspase-8 Activation and Cell Death.  |  Raghawan, AK., et al. 2017. J Biol Chem. 292: 1218-1230. PMID: 27974463
7. Hypoxia-induced increase in Sug1 leads to poor post-transplantation survival of allogeneic mesenchymal stem cells.  |  Abu-El-Rub, E., et al. 2020. FASEB J. 34: 12860-12876. PMID: 32770803
8. SUG1, a putative transcriptional mediator and subunit of the PA700 proteasome regulatory complex, is a DNA helicase.  |  Fraser, RA., et al. 1997. J Biol Chem. 272: 7122-6. PMID: 9054406
9. SUG1, a component of the 26 S proteasome, is an ATPase stimulated by specific RNAs.  |  Makino, Y., et al. 1997. J Biol Chem. 272: 23201-5. PMID: 9287326
10. Interaction of phosducin and phosducin isoforms with a 26S proteasomal subunit, SUG1.  |  Zhu, X. and Craft, CM. 1998. Mol Vis. 4: 13. PMID: 9701609

The preferred SUG1 antibody is SUG1 Antibody (H-7): sc-390631.