Molecular structure of Succinylsulfathiazole, CAS Number: 116-43-8
Succinylsulfathiazole (CAS 116-43-8)
Alternate Names:
p-2-Thiazolylsulfamoylsuccinanilic acid
Application:
Succinylsulfathiazole is an inhibitor of DHFR
CAS Number:
116-43-8
Molecular Weight:
355.39
Molecular Formula:
C13H13N3O5S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Succinylsulfathiazole is a sulfonamide antibiotic that inhibits the synthesis of folic acid in bacteria by acting as a competitive inhibitor of the enzyme dihydropteroate synthase. This disruption of folic acid production ultimately leads to the inhibition of bacterial growth and reproduction. By targeting the folic acid synthesis pathway, succinylsulfathiazole effectively disrupts the ability of bacteria to produce the necessary components for DNA and RNA synthesis. Succinylsulfathiazole has a broad spectrum of activity against both gram-positive and gram-negative bacteria.
Succinylsulfathiazole (CAS 116-43-8) References
- Succinylsulfathiazole crystal forms. III: Crystal growth studies. | Moustafa, MA., et al. 1975. J Pharm Sci. 64: 1485-9. PMID: 1185562
- Interference of lactose in the determination of succinylsulfathiazole. | ANDRADE, JL., et al. 1956. J Am Pharm Assoc Am Pharm Assoc. 45: 446-7. PMID: 13345674
- Lactose diets and cholesterol metabolism. II. Effect of dietary cholesterol, succinylsulfathiazole and mode of feeding on atherogenesis in the rabbit. | Wells, WW., et al. 1962. J Nutr. 76: 41-7. PMID: 14006052
- Influence of succinylsulfathiazole and folic acid on glutamic acid excretion. | BAKERMAN, HA., et al. 1951. J Biol Chem. 188: 117-23. PMID: 14814120
- Cecal Flora of White Rats on Purified Diet and Its Modification by Succinylsulfathiazole. | Evenson, A., et al. 1946. J Bacteriol. 51: 513-21. PMID: 16561104
- Succinylsulfathiazole in resection for carcinoma of the colon; its effect on infection and mortality. | BELL, HG. 1948. Trans West Surg Assoc. 54: 46-50. PMID: 18108730
- Effect of succinylsulfathiazole on the urinary excretion of folic acid by the rabbit. | SIMPSON, RE., et al. 1949. Proc Soc Exp Biol Med. 70: 611. PMID: 18144833
- The effect of succinylsulfathiazole on pteroylglutamic acid deficiency during lactation in the rat. | NELSON, MM. and EVANS, HM. 1948. Arch Biochem. 18: 153-9. PMID: 18871225
- The cecal flora of white rats on a purified diet and its modification by succinylsulfathiazole. | EVENSON, A. and McCOY, E. 1946. J Bacteriol. 51: 513-21. PMID: 20985572
- Observations on the activity in vitro of succinylsulfathiazole and phthalylsulfathiazole. | FLORESTANO, HJ. and KENNEDY, JF. 1946. J Lab Clin Med. 31: 757-62. PMID: 20992878
- Intraperitoneal administration of succinylsulfathiazole and phthalylsulfathiazole; their use in the prophylaxis and treatment of peritonitis. | YOUNG, JP. and COLE, WH. 1946. Arch Surg (1920). 53: 182-9. PMID: 20994768
- Succinylsulfathiazole in the nutrition of the rat. | WRIGHT, LD. and SKEGGS, HR. 1946. Am J Med Sci. 212: 312-4. PMID: 20996977
- The synergistic action of detergents and sulfaguanidine and succinylsulfathiazole. | GERSHENFELD, L. and SAGIN, JF. 1946. Am J Pharm Sci Support Public Health. 118: 228-35. PMID: 21000660
- Succinylsulfathiazole modulates the mTOR signaling pathway in the liver of c57BL/6 mice via a folate independent mechanism. | Beydoun, S., et al. 2021. Exp Gerontol. 150: 111387. PMID: 33957263
- X-ray structural studies and physicochemical characterization of the 1-butanol, 1-pentanol, and 1,4-dioxane solvates of succinylsulfathiazole. | Bourne, SA., et al. 1994. J Pharm Sci. 83: 887-92. PMID: 9120827
Inhibitor of:
DHFR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Succinylsulfathiazole, 100 g | sc-224293 | 100 g | $219.00 | |||
Succinylsulfathiazole, 500 g | sc-224293A | 500 g | $1040.00 |