(Suc-LLVY)2R110
Molecular Weight:
1507.72
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
(Suc-LLVY)2R110 is an exceptionally sensitive fluorogenic substrate employed in the study of 20S proteasome, calpains, and other chymotrypsin-like proteases. This substrate, initially non-fluorescent, undergoes enzymatic cleavage to produce a vivid green fluorescent rhodamine 110 product, easily detectable using a FITC filter set. Compared to AMC-, AFC-, or 4-nitroaniline-based substrates, this rhodamine 110 substrate exhibits heightened sensitivity. Proteasomes, the principal form being the 26S proteasome, comprise a 20S core particle structure flanked by two 19S regulatory caps.
(Suc-LLVY)2R110 References
- Cytotoxic unsaturated electrophilic compounds commonly target the ubiquitin proteasome system. | Selvaraju, K., et al. 2019. Sci Rep. 9: 9841. PMID: 31285509
- Identification of proteasome inhibitors using analysis of gene expression profiles. | Mofers, A., et al. 2020. Eur J Pharmacol. 889: 173709. PMID: 33166494
- M3258 Is a Selective Inhibitor of the Immunoproteasome Subunit LMP7 (β5i) Delivering Efficacy in Multiple Myeloma Models. | Sanderson, MP., et al. 2021. Mol Cancer Ther. 20: 1378-1387. PMID: 34045234
- Erythrocyte type 1 equilibrative nucleoside transporter expression in sickle cell disease and sickle cell trait. | Koehl, B., et al. 2023. Br J Haematol. 200: 812-820. PMID: 36464247
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(Suc-LLVY)2R110, 1 mg | sc-495766 | 1 mg | $123.00 |