Substance P Antibody (NC1/34HL): sc-21715

Substance P Antibody (NC1/34HL) is a rat monoclonal IgG that targets Substance P, a neuropeptide belonging to the tachykinin family and also known as neurokinin-1 (NK1) ligand. Substance P is an 11-amino-acid peptide crucial for transmitting pain signals and mediating inflammatory responses in the nervous system, playing significant roles in pain perception, mood regulation, and neurogenic inflammation. Substance P rat monoclonal antibody (NC1/34HL) binds to an epitope near the C-terminus of Substance P. Substance P monoclonal antibody (NC1/34HL) reacts with Substance P and neurokinins A and B of multiple species origin in immunofluorescence (IF) and immunohistochemistry with paraffin-embedded sections (IHCP) applications, without cross-reactivity to related peptides like [Leu]enkephalin, [Met]enkephalin, somatostatin, or β-endorphin. By detecting Substance P, anti-Substance P antibody (NC1/34HL) aids researchers in studying pain pathways and inflammatory processes, contributing to the development of therapeutic interventions for neurological and immunological disorders. Substance P antibody (NC1/34HL) is available in non-conjugated form and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, providing versatility for different experimental setups. Understanding the function of Substance P is essential, as Substance P interacts with the NK1 receptor to influence vasodilation, cell growth, and immune response, making Substance P a significant target in biomedical research.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Substance P Antibody (NC1/34HL) References:

1. The tachykinin NK1 receptor in the brain: pharmacology and putative functions.  |  Saria, A. 1999. Eur J Pharmacol. 375: 51-60. PMID: 10443564
2. The cytokine-like action of substance P upon B cell differentiation.  |  Pascual, DW., et al. 1992. Reg Immunol. 4: 100-4. PMID: 1380278
3. Substance P promotes sleep in the ventrolateral preoptic area of rats.  |  Zhang, G., et al. 2004. Brain Res. 1028: 225-32. PMID: 15527748
4. Development of an automated in vitro selection protocol to obtain RNA-based aptamers: identification of a biostable substance P antagonist.  |  Eulberg, D., et al. 2005. Nucleic Acids Res. 33: e45. PMID: 15745995
5. IL-12 induction of mRNA encoding substance P in murine macrophages from the spleen and sites of inflammation.  |  Arsenescu, R., et al. 2005. J Immunol. 174: 3906-11. PMID: 15778345
6. Inhibition by spinal mu- and delta-opioid agonists of afferent-evoked substance P release.  |  Kondo, I., et al. 2005. J Neurosci. 25: 3651-60. PMID: 15814796
7. The role of substance P in regulation of blood pressure and hypertension.  |  Chen, J., et al. 1991. Ann N Y Acad Sci. 632: 413-4. PMID: 1719891
8. Substance P-evoked release of GABA from isolated spinal cord of the newborn rat.  |  Sakuma, M., et al. 1991. Neuroscience. 45: 323-30. PMID: 1722288
9. Neuropeptide substance P and the immune response.  |  Mashaghi, A., et al. 2016. Cell Mol Life Sci. 73: 4249-4264. PMID: 27314883
10. Substance P and fibrotic diseases.  |  Peng, L., et al. 2019. Neuropeptides. 76: 101941. PMID: 31256921
11. cDNA sequence of human beta-preprotachykinin, the common precursor to substance P and neurokinin A.  |  Harmar, AJ., et al. 1986. FEBS Lett. 208: 67-72. PMID: 3770210
12. Substance P-induced IL-12 production by murine macrophages.  |  Kincy-Cain, T. and Bost, KL. 1997. J Immunol. 158: 2334-9. PMID: 9036982

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Substance P Antibody (NC1/34HL) has 27 citations in a variety of scientific publications.

Primary antibodies like Anti-Substance P Antibody (NC1/34HL) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Substance P Antibody (NC1/34HL) Specifications

Alternate Product Name: TAC1 tachykinin precursor 1

Product Clone Name: NC1/34HL

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG

Amino Acids:

Epitope Target: Substance P

Epitope Species:

Product Reactivity/Detection: Substance P and Neurokinins A and B

Species Reactivity/Detection: multiple species

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 27 citations in various scientific publications

Available Conjugates/Forms for Substance P Antibody (NC1/34HL): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin