Molecular structure of SU6656, CAS Number: 330161-87-0
SU6656 (CAS 330161-87-0)
See product citations (27)
Alternate Names:
2,3-Dihydro-N,N-dimethyl-2-oxo-3-[(4,5,6,7-tetrahydro-1H-indol-2-yl)methylene]-1H-indole-5-sulfonamide; SU 6656; SU-6656
Application:
SU6656 is a small-molecule inhibitor of potently and selectively inhibits Src tyrosine kinases
CAS Number:
330161-87-0
Purity:
>95%
Molecular Weight:
371.45
Molecular Formula:
C19H21N3O3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
SU6656 is a small-molecule, indolinone which potently and selectively inhibits Src tyrosine kinases, which are known to function in signal transduction pathways. Investigators show that SU6656 causes proliferation abrogation in non-Hodgkin′s lymphoma cell lines and induces megakaryocytic progenitor cell maturation with increased FUT8 fucosyltransferase activity. Further research shows that SU 6656 induced Src tyrosine kinase inhibition attenuates radiation induced Akt phosphorylation, increases radiation-induced apoptosis and increases vascular endothelium destruction in human umbilical vein endothelial cells. This inhibitor serves as a useful tool in elucidating molecular components of cellular signal transduction pathways. SU6656 inhibits c-Src (Src)(IC50 = 280 nM), Fyn (IC50 = 170 nM), c-Yes (IC50 = 20 nM), Lyn (IC50 = 130 nM),Lck (IC50 = 688 muM) and PDGF receptor kinase (IC50 >10muM).
SU6656 (CAS 330161-87-0) References
- SU6656, a selective src family kinase inhibitor, used to probe growth factor signaling. | Blake, RA., et al. 2000. Mol Cell Biol. 20: 9018-27. PMID: 11074000
- Induction of polyploidization in leukemic cell lines and primary bone marrow by Src kinase inhibitor SU6656. | Lannutti, BJ., et al. 2005. Blood. 105: 3875-8. PMID: 15677565
- SRC family kinase inhibitor SU6656 enhances antiangiogenic effect of irradiation. | Cuneo, KC., et al. 2006. Int J Radiat Oncol Biol Phys. 64: 1197-203. PMID: 16504759
- Human B lymphocytes and non-Hodgkin's lymphoma cells become polyploid in response to the protein kinase inhibitor SU6656. | Dussault, N., et al. 2007. Blood Cells Mol Dis. 39: 130-4. PMID: 17434768
- Effects of inhibitor of Src kinases, SU6656, on differentiation of megakaryocytic progenitors and activity of alpha1,6-fucosyltransferase. | Kaminska, J., et al. 2008. Acta Biochim Pol. 55: 499-506. PMID: 18854874
- Simultaneous inhibition of Src and Aurora kinases by SU6656 induces therapeutic synergy in human synovial sarcoma growth, invasion and angiogenesis in vivo. | Arai, R., et al. 2012. Eur J Cancer. 48: 2417-30. PMID: 22244830
- Inhibition of p21 and Akt potentiates SU6656-induced caspase-independent cell death in FRO anaplastic thyroid carcinoma cells. | Kim, SH., et al. 2013. Horm Metab Res. 45: 408-14. PMID: 23386415
- Inhibition of mTORC1 by SU6656, the selective Src kinase inhibitor, is not accompanied by activation of Akt/PKB signalling in melanoma cells. | Ondrušová, L., et al. 2013. Folia Biol (Praha). 59: 162-7. PMID: 24093774
- Dual inhibition of Src family kinases and Aurora kinases by SU6656 modulates CTGF (connective tissue growth factor) expression in an ERK-dependent manner. | Cicha, I., et al. 2014. Int J Biochem Cell Biol. 46: 39-48. PMID: 24275091
- Mechanisms of Paradoxical Activation of AMPK by the Kinase Inhibitors SU6656 and Sorafenib. | Ross, FA., et al. 2017. Cell Chem Biol. 24: 813-824.e4. PMID: 28625738
- Selective inhibition of Src family kinases by SU6656 increases bone mass by uncoupling bone formation from resorption in mice. | Thouverey, C., et al. 2018. Bone. 113: 95-104. PMID: 29751129
- Src family kinase targeting in head and neck tumor cells using SU6656, PP2 and dasatinib. | Vu, AT., et al. 2023. Head Neck. 45: 147-155. PMID: 36285353
- Association of Lyn tyrosine kinase with the nuclear matrix and cell-cycle-dependent changes in matrix-associated tyrosine kinase activity. | Radha, V., et al. 1996. Eur J Biochem. 236: 352-9. PMID: 8612602
Inhibitor of:
A430084P05Rik, AFAP-1L1, BC057022, BCAR3, BDCA-2, c-Fgr, c-Src, c-Yes, C230052I12Rik, C230055K05Rik, Cd302, CD32-B_Fc γ RIIb, CESK1, CIB, CLEC-2B, CNIH2, Contrin, Crk-L, Csk, Draxin, Enzyme, ephrin-B2, Fyn, G6b_AU023871, KIAA1751, KIR2DS4, Lck BP-1, Liprin α2, LOC644297, LRFN2, Lyn, MAIR-II, MPZL3, MRGG, MS4A4C, Mucin 20, Myopodin, neuroligin 2, OCR1, p140Cap, PCDGF, PID1, Rak (FRK), Reelin, REPS2, Sck, SH2D (SH2 domain containing protein), SH3PXD2B, SH3YL1, Sin, Slp5, STS-1, TESK1, Tns2, TSPAN2, TSSK 1, TULA, Tyrosine Kinase, and ZNF609.Activator of:
ADAM30, c-Src, Cdc16, CNOT4, EDD, FGF-18, Fyn, GRB7, Integrin α9, MA1, NSP3, P23, PID1, and PTPRCAP.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SU6656, 1 mg | sc-203286 | 1 mg | $56.00 | |||
SU6656, 5 mg | sc-203286A | 5 mg | $130.00 |