Molecular structure of SU11652, CAS Number: 326914-10-7
SU11652 (CAS 326914-10-7)
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Alternate Names:
5-[(Z)-(5-chloro-1, 2-dihydro-2-oxo-3H-indol-3- ylidene)methyl]-N-[2-(diethylamino)ethyl]-2, 4-dimethyl-1H-pyrrole-3-carboxamide
Application:
SU11652 is a cell-permeable pyrrole-indolinone that acts as a tyrosine kinase receptor & angiogenic inhibitor
CAS Number:
326914-10-7
Purity:
>97%
Molecular Weight:
414.90
Molecular Formula:
C22H27ClN4O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
SU11652 is a potent cell-permeable pyrrole-indolinone compound that acts as an ATP-competitive tyrosine kinase receptor and angiogenic inhibitor that exhibits greater selectivity for PDGFR-beta (PDGFRbeta, IC50 = 3 nM), Flk-1 (VEGFR2, IC50 = 27 nM), FGFR1 (IC50= 170 nM), and Kit family members (IC50=~10-500 nM) over EGFR (IC50 >20 muM). SU11652 displays anti-proliferative and pro-apoptotic properties in tumor cells.
SU11652 (CAS 326914-10-7) References
- Inhibition of constitutively active forms of mutant kit by multitargeted indolinone tyrosine kinase inhibitors. | Liao, AT., et al. 2002. Blood. 100: 585-93. PMID: 12091352
- Effect of angiogenesis inhibitors on oestrogen-mediated endometrial endothelial cell proliferation in the ovariectomized mouse. | Heryanto, B., et al. 2003. Reproduction. 125: 337-46. PMID: 12611597
- Insights for the development of specific kinase inhibitors by targeted structural genomics. | Fedorov, O., et al. 2007. Drug Discov Today. 12: 365-72. PMID: 17467572
- Generation of FGF reporter transgenic zebrafish and their utility in chemical screens. | Molina, GA., et al. 2007. BMC Dev Biol. 7: 62. PMID: 17553162
- Heat-shock protein 90 associates with N-terminal extended peptides and is required for direct and indirect antigen presentation. | Callahan, MK., et al. 2008. Proc Natl Acad Sci U S A. 105: 1662-7. PMID: 18216248
- Stimulatory effect of benzylidenemalononitrile tyrphostins on expression of NO-dependent genes in U-937 monocytic cells. | Turpaev, K. and Drapier, JC. 2009. Eur J Pharmacol. 606: 1-8. PMID: 19374863
- SU11652 Inhibits tyrosine kinase activity of FLT3 and growth of MV-4-11 cells. | Guo, Y., et al. 2012. J Hematol Oncol. 5: 72. PMID: 23216927
- Sunitinib and SU11652 inhibit acid sphingomyelinase, destabilize lysosomes, and inhibit multidrug resistance. | Ellegaard, AM., et al. 2013. Mol Cancer Ther. 12: 2018-30. PMID: 23920274
- FGF-2 released from degenerating neurons exerts microglial-induced neuroprotection via FGFR3-ERK signaling pathway. | Noda, M., et al. 2014. J Neuroinflammation. 11: 76. PMID: 24735639
- Involvement of platelet-derived growth factor receptor β in fibrosis through extracellular matrix protein production after ischemic stroke. | Makihara, N., et al. 2015. Exp Neurol. 264: 127-34. PMID: 25510317
- Inhibition of mTOR-kinase destabilizes MYCN and is a potential therapy for MYCN-dependent tumors. | Vaughan, L., et al. 2016. Oncotarget. 7: 57525-57544. PMID: 27438153
- Pyrrole-indolinone SU11652 targets the nucleoside diphosphate kinase from Leishmania parasites. | Vieira, PS., et al. 2017. Biochem Biophys Res Commun. 488: 461-465. PMID: 28499874
- Sunitinib inhibits RNase L by destabilizing its active dimer conformation. | Tang, J., et al. 2020. Biochem J. 477: 3387-3399. PMID: 32830849
- Effect of genistein on regenerative angiogenesis using zebrafish as model organism | Vivek Sagayaraj Rathinasamy, Navina Paneerselvan, Malathi Ragunathan. 2014. Biomedicine & Preventive Nutrition. 4: 469-474.
Inhibitor of:
c-Kit, Flk-1, and PDGFR-beta.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SU11652, 500 µg | sc-204310 | 500 µg | $172.00 | |||
SU11652, 1 mg | sc-204310A | 1 mg | $402.00 | |||
SU11652, 10 mg | sc-204310B | 10 mg | $2087.00 | |||
SU11652, 25 mg | sc-204310C | 25 mg | $3648.00 |