Molecular structure of SU 4312, CAS Number: 5812-07-7
SU 4312 (CAS 5812-07-7)
See product citations (2)
Application:
SU 4312 is a potent and selective VEGFR (Flk/Flt) inhibitor
CAS Number:
5812-07-7
Purity:
98%
Molecular Weight:
264.3
Molecular Formula:
C17H16N2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
SU 4312 is a selective and potent vascular endothelial cell growth factor receptor (VEGFR) inhibitor. Inhibition of VEGFR-2 in neonatal rodent models of stroke, has been shown to limit endothelial cell proliferation and promote cell death. It has been suggested that SU 4312 may interfere with endothelial cell activation in azheimer′s disease because it could block vessel formation.
SU 4312 (CAS 5812-07-7) References
- In vivo characterization of endothelial cell activation in a transgenic mouse model of Alzheimer's disease. | Schultheiss, C., et al. 2006. Angiogenesis. 9: 59-65. PMID: 16821113
- Vascular endothelial growth factor receptor-2 inhibition promotes cell death and limits endothelial cell proliferation in a neonatal rodent model of stroke. | Shimotake, J., et al. 2010. Stroke. 41: 343-9. PMID: 20101028
- Prolonged blockade of VEGF receptors does not damage retinal photoreceptors or ganglion cells. | Miki, A., et al. 2010. J Cell Physiol. 224: 262-72. PMID: 20232317
- The anti-cancer agent SU4312 unexpectedly protects against MPP(+) -induced neurotoxicity via selective and direct inhibition of neuronal NOS. | Cui, W., et al. 2013. Br J Pharmacol. 168: 1201-14. PMID: 23062100
- Vascular Endothelial Growth Factor-A (VEGF-A) Mediates Activin A-Induced Human Trophoblast Endothelial-Like Tube Formation. | Li, Y., et al. 2015. Endocrinology. 156: 4257-68. PMID: 26327470
- Substantial protection against MPTP-associated Parkinson's neurotoxicity in vitro and in vivo by anti-cancer agent SU4312 via activation of MEF2D and inhibition of MAO-B. | Guo, B., et al. 2017. Neuropharmacology. 126: 12-24. PMID: 28807675
- Inhibitors of the VEGF Receptor Suppress HeLa S3 Cell Proliferation via Misalignment of Chromosomes and Rotation of the Mitotic Spindle, Causing a Delay in M-Phase Progression. | Okumura, D., et al. 2018. Int J Mol Sci. 19: PMID: 30545129
Inhibitor of:
Angiogenesis, E130203B14Rik, FEM-3, Flg, Flk-1, Flt-1, PDGF-C, and PDGFR-beta.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SU 4312, 5 mg | sc-200637 | 5 mg | $97.00 | |||
SU 4312, 25 mg | sc-200637A | 25 mg | $360.00 |