Molecular structure of SU 3327, CAS Number: 40045-50-9
SU 3327 (CAS 40045-50-9)
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Alternate Names:
5-[(5-Nitro-2-thiazolyl)thio]-1,3,4thiadiazol-2-amine
Application:
SU 3327 is a selective inhibitor of JNK shown to inhibit the protein-protein interaction between JNK and JIP
CAS Number:
40045-50-9
Purity:
≥95%
Molecular Weight:
261.3
Molecular Formula:
C5H3N5O2S3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
SU 3327 is a selective inhibitor of JNK (c-Jun N-terminal kinase)(IC50 = 0.7μM). SU 3327 is shown to inhibit the protein-protein interaction between JNK and JIP (IC50 = 239 nM).
SU 3327 (CAS 40045-50-9) References
- Design, synthesis, and structure-activity relationship of substrate competitive, selective, and in vivo active triazole and thiadiazole inhibitors of the c-Jun N-terminal kinase. | De, SK., et al. 2009. J Med Chem. 52: 1943-52. PMID: 19271755
- Traumatic injury elicits JNK-mediated human astrocyte retraction in vitro. | Augustine, C., et al. 2014. Neuroscience. 274: 1-10. PMID: 24838066
- Inhibition of JNK aggravates the recovery of rat hearts after global ischemia: the role of mitochondrial JNK. | Jang, S. and Javadov, S. 2014. PLoS One. 9: e113526. PMID: 25423094
- Critical role of c-jun N-terminal protein kinase in promoting mitochondrial dysfunction and acute liver injury. | Jang, S., et al. 2015. Redox Biol. 6: 552-564. PMID: 26491845
- Gigantol ameliorates CCl4-induced liver injury via preventing activation of JNK/cPLA2/12-LOX inflammatory pathway. | Xue, Y., et al. 2020. Sci Rep. 10: 22265. PMID: 33335297
- Sex and dose-dependent antinociceptive effects of the JNK (c-Jun N-terminal kinase) inhibitor SU 3327 are mediated by CB2 receptors in female, and CB1/CB2 receptors in male mice in an inflammatory pain model. | Blanton, HL., et al. 2021. Brain Res Bull. 177: 39-52. PMID: 34530070
- Halicin Is Effective Against Staphylococcus aureus Biofilms In Vitro. | Higashihira, S., et al. 2022. Clin Orthop Relat Res. 480: 1476-1487. PMID: 35583504
- Repurposing Halicin as a potent covalent inhibitor for the SARS-CoV-2 main protease. | Yang, KS., et al. 2022. Curr Res Chem Biol. 2: 100025. PMID: 35815070
- Study on antibacterial effect of halicin (SU3327) against Enterococcus faecalis and Enterococcus faecium. | Hussain, Z., et al. 2022. Pathog Dis. 80: PMID: 36152595
- Halicin: A New Horizon in Antibacterial Therapy against Veterinary Pathogens. | Wang, S., et al. 2024. Antibiotics (Basel). 13: PMID: 38927159
Inhibitor of:
JNK, MAP-9, and Ser/Thr Protein Kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SU 3327, 10 mg | sc-296430 | 10 mg | $169.00 | |||
SU 3327, 50 mg | sc-296430A | 50 mg | $715.00 |