STYX Antibody (D-12): sc-398023
- STYX Antibody (D-12) is a mouse monoclonal IgG2b κ STYX antibody provided at 200 µg/ml
- raised against amino acids 134-223 mapping at the C-terminus of STYX of human origin
- STYX Antibody (D-12) is recommended for detection of STYX of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-STYX Antibody (D-12) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG2b BP-HRP are the preferred secondary detection reagents for STYX Antibody (D-12) for WB applications. These reagents are now offered in bundles with STYX Antibody (D-12) (see ordering information below).
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SEE ALSO...
STYX Antibody (D-12) is a mouse monoclonal IgG2b kappa light chain antibody that detects STYX protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). STYX (D-12) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. STYX protein, also known as serine/threonine/tyrosine-interacting protein, is a 223 amino acid protein that belongs to the protein-tyrosine phosphatase family, specifically the non-receptor class subfamily. Notably, STYX contains a Gly residue instead of the conserved Cys residue typically found in the dsPTPase catalytic loop, rendering STYX catalytically inactive as a phosphatase. However, the preserved binding pocket allows STYX to interact with phosphorylated substrates, potentially shielding them from degradation by active phosphatases. This interaction is crucial as STYX may play a significant role in cellular signaling pathways, particularly during spermiogenesis, where STYX interacts with CARHSP1/CRHSP-24. The gene encoding STYX is located on human chromosome 14, which is home to over 700 genes and is implicated in various genetic disorders, including Alzheimer′s disease and α1-antitrypsin deficiency. The ability of STYX to bind phosphorylated proteins highlights STYX′s importance in maintaining cellular homeostasis and regulating critical biological processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
STYX Antibody (D-12) References:
- The design of parallel hole gamma camera collimators. | Causer, DA. 1975. Int J Appl Radiat Isot. 26: 355-62. PMID: 1184222
- Proteomics analysis of a novel compound: cyclic RGD in breast carcinoma cell line MCF-7. | Juan, HF., et al. 2006. Proteomics. 6: 2991-3000. PMID: 16619296
- Genotype-phenotype relationships of presenilin-1 mutations in Alzheimer's disease: an update. | Larner, AJ. and Doran, M. 2009. J Alzheimers Dis. 17: 259-65. PMID: 19221408
- Identification of potentially damaging amino acid substitutions leading to human male infertility. | Kuzmin, A., et al. 2009. Biol Reprod. 81: 319-26. PMID: 19369647
- Alpha-1-antitrypsin phenotypes in adult liver disease patients. | Topic, A., et al. 2009. Ups J Med Sci. 114: 228-34. PMID: 19961268
- A single mutation converts a novel phosphotyrosine binding domain into a dual-specificity phosphatase. | Wishart, MJ., et al. 1995. J Biol Chem. 270: 26782-5. PMID: 7592916
- Multiple phosphotyrosine phosphatase mRNAs are expressed in the human lung fibroblast cell line WI-38. | Dayton, MA. and Knobloch, TJ. 1997. Recept Signal Transduct. 7: 241-56. PMID: 9633825
- Gathering STYX: phosphatase-like form predicts functions for unique protein-interaction domains. | Wishart, MJ. and Dixon, JE. 1998. Trends Biochem Sci. 23: 301-6. PMID: 9757831
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
STYX Antibody (D-12) | sc-398023 | 200 µg/ml | $322.00 | |||
STYX Antibody (D-12): m-IgG Fc BP-HRP Bundle | sc-526281 | 200 µg Ab; 10 µg BP | $361.00 | |||
STYX Antibody (D-12): m-IgG2b BP-HRP Bundle | sc-549705 | 200 µg Ab; 10 µg BP | $361.00 | |||
STYX Antibody (D-12) AC | sc-398023 AC | 500 µg/ml, 25% agarose | $424.00 | |||
STYX Antibody (D-12) HRP | sc-398023 HRP | 200 µg/ml | $322.00 | |||
STYX Antibody (D-12) FITC | sc-398023 FITC | 200 µg/ml | $336.00 | |||
STYX Antibody (D-12) PE | sc-398023 PE | 200 µg/ml | $349.00 | |||
STYX Antibody (D-12) Alexa Fluor® 488 | sc-398023 AF488 | 200 µg/ml | $364.00 | |||
STYX Antibody (D-12) Alexa Fluor® 546 | sc-398023 AF546 | 200 µg/ml | $364.00 | |||
STYX Antibody (D-12) Alexa Fluor® 594 | sc-398023 AF594 | 200 µg/ml | $364.00 | |||
STYX Antibody (D-12) Alexa Fluor® 647 | sc-398023 AF647 | 200 µg/ml | $364.00 | |||
STYX Antibody (D-12) Alexa Fluor® 680 | sc-398023 AF680 | 200 µg/ml | $364.00 | |||
STYX Antibody (D-12) Alexa Fluor® 790 | sc-398023 AF790 | 200 µg/ml | $364.00 |