STRO-1 Antibody (STRO-1): sc-47733

STRO-1 Antibody (STRO-1) is a mouse monoclonal IgM antibody that detects STRO-1 by immunofluorescence (IF) and flow cytometry (FCM). Anti-STRO-1 antibody (STRO-1) is available in non-conjugated and various conjugated forms, including horseradish peroxidase (HRP), phycoerythrin (PE), and fluorescein isothiocyanate (FITC). STRO-1 plays a crucial role as a surface marker for mesenchymal stem cells (MSCs), which are pivotal in regenerative medicine due to their ability to differentiate into various cell types, including adipocytes, osteoblasts, and chondrocytes. The identification and isolation of STRO-1+ MSCs from human tissues, such as bone marrow and dental pulp, are essential for advancing cell-based therapies aimed at treating a range of human diseases. Notably, STRO-1+ enriched subset of marrow cells can support hematopoiesis and exhibit a vascular smooth muscle-like phenotype, highlighting their potential in tissue engineering and regenerative applications. The ability to enrich fibroblast colony-forming cells (CFU-F) approximately 100-fold in a STRO-1+/Glycophorin A- population compared to the STRO-1+/Glycophorin A+ population underscores STRO-1′s importance in stem cell research and therapeutic development.

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STRO-1 Antibody (STRO-1) References:

1. Osteoblastic differentiation and mRNA analysis of STRO-1-positive human bone marrow stromal cells using primary in vitro culture and poly (A) PCR.  |  Byers, RJ., et al. 1999. J Pathol. 187: 374-81. PMID: 10398094
2. Bone formation by human postnatal bone marrow stromal stem cells is enhanced by telomerase expression.  |  Shi, S., et al. 2002. Nat Biotechnol. 20: 587-91. PMID: 12042862
3. Fetal liver stroma consists of cells in epithelial-to-mesenchymal transition.  |  Chagraoui, J., et al. 2003. Blood. 101: 2973-82. PMID: 12506029
4. Differential expression of stem cell mobilization-associated molecules on multi-lineage cells from adipose tissue and bone marrow.  |  De Ugarte, DA., et al. 2003. Immunol Lett. 89: 267-70. PMID: 14556988
5. Characterization of multipotential mesenchymal progenitor cells derived from human trabecular bone.  |  Tuli, R., et al. 2003. Stem Cells. 21: 681-93. PMID: 14595128
6. Homing of in vitro expanded Stro-1- or Stro-1+ human mesenchymal stem cells into the NOD/SCID mouse and their role in supporting human CD34 cell engraftment.  |  Bensidhoum, M., et al. 2004. Blood. 103: 3313-9. PMID: 14715641
7. Investigation of multipotent postnatal stem cells from human periodontal ligament.  |  Seo, BM., et al. Lancet. 364: 149-55. PMID: 15246727
8. Stromal-derived factor-1 promotes the growth, survival, and development of human bone marrow stromal stem cells.  |  Kortesidis, A., et al. 2005. Blood. 105: 3793-801. PMID: 15677562
9. An approachable human adult stem cell source for hard-tissue engineering.  |  Laino, G., et al. 2006. J Cell Physiol. 206: 693-701. PMID: 16222704
10. Stem-like cells in bone sarcomas: implications for tumorigenesis.  |  Gibbs, CP., et al. 2005. Neoplasia. 7: 967-76. PMID: 16331882
11. Mesenchymal STRO-1/STRO-3+ precursor cells for the treatment of chronic heart failure with reduced ejection fraction.  |  Sundin, A., et al. 2023. Future Cardiol. 19: 567-581. PMID: 37933628
12. Isolation, characterization and functional activity of human marrow stromal progenitors in hemopoiesis.  |  Simmons, PJ., et al. 1994. Prog Clin Biol Res. 389: 271-80. PMID: 7700911

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-STRO-1 Antibody (STRO-1) has 59 citations in a variety of scientific publications.

Primary antibodies like Anti-STRO-1 Antibody (STRO-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

STRO-1 Antibody (STRO-1) Specifications

Alternate Product Name: STRO-1

Product Clone Name: STRO-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids:

Epitope Target: STRO-1

Epitope Species: human

Product Reactivity/Detection: STRO-1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: IF, FCM

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 59 citations in various scientific publications

Available Conjugates/Forms for STRO-1 Antibody (STRO-1): FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin, PerCP: Peridinin Chlorophyll Protein Complex with Cyanin-5.5