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Streptozotocin (U-9889) (CAS 18883-66-4) - chemical structure image
Molecular structure of Streptozotocin (U-9889), CAS Number: 18883-66-4
Streptozotocin (U-9889) (CAS 18883-66-4) - chemical structure image
Molecular structure of Streptozotocin (U-9889), CAS Number: 18883-66-4
Molecular structure of Streptozotocin (U-9889), CAS Number: 18883-66-4

Streptozotocin (U-9889) (CAS 18883-66-4)

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Alternate Names:
Streptozotocin (U-9889) is also known as STZ and Zanosar
Application:
Streptozotocin (U-9889) is an N-nitroso containing antibiotic and can be used as a potent DNA methylating agent.
CAS Number:
18883-66-4
Purity:
≥98%
Molecular Weight:
265.20
Molecular Formula:
C8H15N3O7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Description
Technical Information
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SDS & Certificate of Analysis

Streptozotocin (U-9889) is recognized in the research community for its capability to selectively target pancreatic beta cells. In cellular studies, it is used to investigate the mechanisms of beta-cell dysfunction, providing insights into the cellular and molecular pathways that lead to the loss of insulin secretion. Streptozotocin is also utilized in biochemical assays to elucidate the cellular response to DNA damage, as it acts as an alkylating agent, introducing modifications to the DNA structure. In glucose metabolism research, streptozotocin is applied to understand the effects of insulin deficiency at a cellular level. Furthermore, the compound serves as a tool to study potential protective mechanisms against beta-cell cytotoxicity, which is relevant in the context of identifying molecular targets for supporting beta-cell viability.


Streptozotocin (U-9889) (CAS 18883-66-4) References

  1. Antinociceptive effect of U-50488H, a kappa-opioid agonist, in streptozotocin-induced diabetic mice.  |  Suzuki, Y., et al. 2001. J Pharm Pharmacol. 53: 521-6. PMID: 11341369
  2. Islet cell tumors of the pancreas: the medical oncologist's perspective.  |  Brentjens, R. and Saltz, L. 2001. Surg Clin North Am. 81: 527-42. PMID: 11459269
  3. The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas.  |  Szkudelski, T. 2001. Physiol Res. 50: 537-46. PMID: 11829314
  4. Differential expression of GLUT2 in pancreatic islets and kidneys of New and Old World nonhuman primates.  |  Kramer, J., et al. 2009. Am J Physiol Regul Integr Comp Physiol. 296: R786-93. PMID: 19073904
  5. Streptozotocin-induced diabetic models in mice and rats.  |  Wu, KK. and Huan, Y. 2008. Curr Protoc Pharmacol. Chapter 5: Unit 5.47. PMID: 22294227
  6. Streptozotocin-associated lymphopenia in cynomolgus monkeys.  |  Nagaraju, S., et al. 2014. Islets. 6: e944441. PMID: 25322828
  7. Periostin induces pancreatic regeneration.  |  Smid, JK., et al. 2015. Endocrinology. 156: 824-36. PMID: 25485969
  8. Effects of diabetes on apoptosis and mitosis in rat hippocampus.  |  Ünver Saraydin, S., et al. 2021. Biotech Histochem. 96: 460-467. PMID: 32938250
  9. Streptozotocin-induced type 1 and 2 diabetes in rodents: a model for studying diabetic cardiac autonomic neuropathy.  |  Akinlade, OM., et al. 2021. Afr Health Sci. 21: 719-727. PMID: 34795728
  10. MORPHOLOGICAL CHARACTERISTICS OF DIABETIC GLOSSITIS.  |  Zhurakivska, OY. and Atamanchuk, OV. 2022. Wiad Lek. 75: 619-623. PMID: 35522867
  11. O-Methylation of carboxylic acids with streptozotocin.  |  Zeng, LY., et al. 2022. Org Biomol Chem. 20: 5230-5233. PMID: 35621003
  12. Changes in phrenic nerve compound muscle action potential in streptozotocin-induced diabetic rats.  |  Ferrari, MC., et al. 2022. Respir Physiol Neurobiol. 303: 103923. PMID: 35654367
  13. Streptozotocin-induced Alzheimer's disease investigation by one-dimensional plasmonic grating chip.  |  Kadhim, HJ., et al. 2022. Sci Rep. 12: 21878. PMID: 36536049
  14. Alkylation of DNA in rat tissues following administration of streptozotocin.  |  Bennett, RA. and Pegg, AE. 1981. Cancer Res. 41: 2786-90. PMID: 6454479

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Streptozotocin (U-9889), 1 g

sc-200719
1 g
$110.00

Streptozotocin (U-9889), 5 g

sc-200719A
5 g
$510.00

Hi :I would be appreciating if you would refer me to published articles that were dependent on STZ, Santa CRRUZ, for induction of diabetes

Asked by: Aliaa
Thank you for your question. It would be helpful if you could call us, allowing for a more interactive discussion of this and other related questions.
Answered by: Technical Support
Date published: 2021-07-22

Hello; we will use it our experimental animals (rat), for make diabets, How many milligrams should we give per animals..?

Asked by: Rota35
Unfortunately we are not able to provide that information. Our compounds are not pharmaceutical grade and not manufactured under GMP guidelines. Please consult your principal investigator and your animal care and use committee (ACUC) regarding the use of our compounds.
Answered by: Technical Support
Date published: 2020-05-27

What is the appearance of the compound?

Asked by: two2igm05
The compound is pale yellow crystalline powder.
Answered by: Chemical Support 4
Date published: 2017-02-25

Eu sou da UEPG, Universidade Estadual de Ponta Grossa-Pr, solicito orçamento do produto: STREPTOZOTOCIN 1g, para compra direta, juntamente com os dados de sua empresa, obrigado. Nosso cnpj é 80.257.355/0001-08, meu nome é José Claudinei de Arruda.

Asked by: Arruda
Thank you for your question. Please contact one of our authorized distributors in Brazil to receive a quote for this chemical, sc-200719: Streptozotocin (U-9889). A complete list of our distributors can be found using the link below, or by selecting Distributors, under Resources in the menu at the bottom of our website. https://www3.scbt.com/scbt/resources/distributors
Answered by: Technical Support
Date published: 2016-09-19
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Rated 5 out of 5 by from 500 mg packet for STZI would like to buy STZ for diabetes model. Do you have a 500 mg packet of STZ, or is the smallest packet 1 mg?
Date published: 2023-07-21
Rated 5 out of 5 by from Fast deliveryFast delivery, good quality, will order again when needed
Date published: 2022-11-24
Rated 5 out of 5 by from Great product and staffExcellent product, fast shipping and great team to help me chose the right product! 100% reccomand!
Date published: 2021-03-21
Rated 5 out of 5 by from Great featureI bought this product a month ago. Delivery was very fast and the price is great. Excellent product.
Date published: 2018-04-25
Rated 5 out of 5 by from Thanks SCBTI bought 2gm STZ from SCBT one month ago and I got it so fast. STZ was very effective and very good price.
Date published: 2017-01-19
Rated 5 out of 5 by from Great features!I bought this a month ago and have used it to successfully induce the diabetic model in mice!
Date published: 2016-12-19
Rated 5 out of 5 by from SantosSantos, et al (PubMed ID 19096034) found that streptozotocin increases BACE levels, AChE activity and oxidative stress in the mouse hippocampus. Also confirmed that cognitive impairment was achieved by the use of STZ. -SCBT Publication Review
Date published: 2015-06-24
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Streptozotocin (U-9889) is rated 5.0 out of 5 by 7.
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