Streptozotocin (U-9889) (CAS 18883-66-4)
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Streptozotocin (U-9889) is recognized in the research community for its capability to selectively target pancreatic beta cells. In cellular studies, it is used to investigate the mechanisms of beta-cell dysfunction, providing insights into the cellular and molecular pathways that lead to the loss of insulin secretion. Streptozotocin is also utilized in biochemical assays to elucidate the cellular response to DNA damage, as it acts as an alkylating agent, introducing modifications to the DNA structure. In glucose metabolism research, streptozotocin is applied to understand the effects of insulin deficiency at a cellular level. Furthermore, the compound serves as a tool to study potential protective mechanisms against beta-cell cytotoxicity, which is relevant in the context of identifying molecular targets for supporting beta-cell viability.
Streptozotocin (U-9889) (CAS 18883-66-4) References
- Antinociceptive effect of U-50488H, a kappa-opioid agonist, in streptozotocin-induced diabetic mice. | Suzuki, Y., et al. 2001. J Pharm Pharmacol. 53: 521-6. PMID: 11341369
- Islet cell tumors of the pancreas: the medical oncologist's perspective. | Brentjens, R. and Saltz, L. 2001. Surg Clin North Am. 81: 527-42. PMID: 11459269
- The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. | Szkudelski, T. 2001. Physiol Res. 50: 537-46. PMID: 11829314
- Differential expression of GLUT2 in pancreatic islets and kidneys of New and Old World nonhuman primates. | Kramer, J., et al. 2009. Am J Physiol Regul Integr Comp Physiol. 296: R786-93. PMID: 19073904
- Streptozotocin-induced diabetic models in mice and rats. | Wu, KK. and Huan, Y. 2008. Curr Protoc Pharmacol. Chapter 5: Unit 5.47. PMID: 22294227
- Streptozotocin-associated lymphopenia in cynomolgus monkeys. | Nagaraju, S., et al. 2014. Islets. 6: e944441. PMID: 25322828
- Periostin induces pancreatic regeneration. | Smid, JK., et al. 2015. Endocrinology. 156: 824-36. PMID: 25485969
- Effects of diabetes on apoptosis and mitosis in rat hippocampus. | Ünver Saraydin, S., et al. 2021. Biotech Histochem. 96: 460-467. PMID: 32938250
- Streptozotocin-induced type 1 and 2 diabetes in rodents: a model for studying diabetic cardiac autonomic neuropathy. | Akinlade, OM., et al. 2021. Afr Health Sci. 21: 719-727. PMID: 34795728
- MORPHOLOGICAL CHARACTERISTICS OF DIABETIC GLOSSITIS. | Zhurakivska, OY. and Atamanchuk, OV. 2022. Wiad Lek. 75: 619-623. PMID: 35522867
- O-Methylation of carboxylic acids with streptozotocin. | Zeng, LY., et al. 2022. Org Biomol Chem. 20: 5230-5233. PMID: 35621003
- Changes in phrenic nerve compound muscle action potential in streptozotocin-induced diabetic rats. | Ferrari, MC., et al. 2022. Respir Physiol Neurobiol. 303: 103923. PMID: 35654367
- Streptozotocin-induced Alzheimer's disease investigation by one-dimensional plasmonic grating chip. | Kadhim, HJ., et al. 2022. Sci Rep. 12: 21878. PMID: 36536049
- Alkylation of DNA in rat tissues following administration of streptozotocin. | Bennett, RA. and Pegg, AE. 1981. Cancer Res. 41: 2786-90. PMID: 6454479
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Streptozotocin (U-9889), 1 g | sc-200719 | 1 g | $116.00 | |||
Streptozotocin (U-9889), 5 g | sc-200719A | 5 g | $530.00 |