Molecular structure of STO-609 acetate salt, CAS Number: 1173022-21-3
STO-609 acetate salt (CAS 1173022-21-3)
See product citations (19)
Alternate Names:
7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid, acetate salt
Application:
STO-609 acetate salt is a selective CaMKK inhibitor
CAS Number:
1173022-21-3
Purity:
≥98%
Molecular Weight:
374.35
Molecular Formula:
C19H10N2O3•C2H4O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
STO-609 is a naphthoyl fused benzimidazole cell-permeable compound. It is known to be a very potent and selective ATP-competitive CaMKK inhibitor. STO-609 may act to bind to the CaMKK catalytic domain, thus inhibiting autophosphorylation. STO-609 has not been found to significantly affect the activities of MLCK, CaMKII, CaMKI, CaMKIV, PKC, PKA, or p42 MAP kinase. It has been observed to inhibit AMP-activated protein kinase phosphorylation. STO-609 is an inhibitor of CaMKK alpha and CaMKK beta and an activator of aryl hydrocarbon receptor.
STO-609 acetate salt (CAS 1173022-21-3) References
- STO-609, a specific inhibitor of the Ca(2+)/calmodulin-dependent protein kinase kinase. | Tokumitsu, H., et al. 2002. J Biol Chem. 277: 15813-8. PMID: 11867640
- A single amino acid difference between alpha and beta Ca2+/calmodulin-dependent protein kinase kinase dictates sensitivity to the specific inhibitor, STO-609. | Tokumitsu, H., et al. 2003. J Biol Chem. 278: 10908-13. PMID: 12540834
- Agonist-modulated regulation of AMP-activated protein kinase (AMPK) in endothelial cells. Evidence for an AMPK -> Rac1 -> Akt -> endothelial nitric-oxide synthase pathway. | Levine, YC., et al. 2007. J Biol Chem. 282: 20351-64. PMID: 17519230
- Chemerin reverses neurological impairments and ameliorates neuronal apoptosis through ChemR23/CAMKK2/AMPK pathway in neonatal hypoxic-ischemic encephalopathy. | Zhang, Y., et al. 2019. Cell Death Dis. 10: 97. PMID: 30718467
Inhibitor of:
AMPK, CaMKK alpha, and CaMKK beta.Activator of:
Aryl Hydrocarbon Receptor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
STO-609 acetate salt, 5 mg | sc-202820 | 5 mg | $103.00 |