STK40 Antibody (LN-87): sc-130476
- STK40 Antibody (LN-87) is a mouse monoclonal IgG2a κ STK40 antibody provided at 100 µg/ml
- raised against recombinant STK40 of human origin
- recommended for detection of STK40 of mouse, rat and human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for STK40 Antibody (LN-87). This work is in progress.
STK40 Antibody (LN-87) is a mouse monoclonal IgG2a kappa light chain antibody that detects STK40 protein of mouse, rat, and human origin by western blotting (WB) and immunoprecipitation (IP). Anti-STK40 antibody (LN-87) is available as a non-conjugated format. STK40, also known as Serine/threonine-protein kinase 40 or Sugen kinase 495, is a 435 amino acid protein kinase that plays a crucial role in cellular signaling pathways, particularly as a potential negative regulator of NFκB and p53-mediated gene expression. STK40 is localized in both the cytoplasm and nucleus, which enables participation in various cellular processes, including cell proliferation and apoptosis. STK40 contains a central serine/threonine protein kinase domain and shares homology with TRB-3, a protein known to regulate MAP kinases activation and inhibit NFκB-mediated gene transcription. Overexpression of STK40 has been shown to inhibit NFκB activation triggered by tumor necrosis factor (TNF) and suppress p53-mediated transcription, highlighting a potential role in cancer biology. Four named isoforms of STK40 are produced through alternative splicing, which may contribute to functional diversity in different cellular contexts.
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STK40 Antibody (LN-87) References:
- The protein kinase complement of the human genome. | Manning, G., et al. 2002. Science. 298: 1912-34. PMID: 12471243
- SINK is a p65-interacting negative regulator of NF-kappaB-dependent transcription. | Wu, M., et al. 2003. J Biol Chem. 278: 27072-9. PMID: 12736262
- TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver. | Du, K., et al. 2003. Science. 300: 1574-7. PMID: 12791994
- Identification of a novel serine/threonine kinase that inhibits TNF-induced NF-kappaB activation and p53-induced transcription. | Huang, J., et al. 2003. Biochem Biophys Res Commun. 309: 774-8. PMID: 13679039
- Patterns of somatic mutation in human cancer genomes. | Greenman, C., et al. 2007. Nature. 446: 153-8. PMID: 17344846
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
STK40 Antibody (LN-87) | sc-130476 | 100 µg/ml | $333.00 |