Stiripentol (CAS 49763-96-4)
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Stiripentol is a chemical compound that has gained interest in various research studies focused on its influence on gamma-aminobutyric acid (GABA) neurotransmission. In neuroscientific research, stiripentol is particularly useful for studying GABAergic mechanisms due to its properties as a GABAergic positive allosteric modulator. Its ability to enhance GABA activity at GABA-A receptors has made it a subject of investigation in the context of neuronal excitability and inhibitory neurotransmission. Moreover, stiripentol is utilized in research to understand its effects on certain types of ion channels and neurotransmitter transporters. Studies involving stiripentol also delve into its impact on metabolic pathways in the brain, such as its interactions with cytochrome P450 enzymes, which are important for the metabolism of various endogenous and exogenous substances.
Stiripentol (CAS 49763-96-4) References
- Compounds exhibiting selective efficacy for different beta subunits of human recombinant gamma-aminobutyric acid A receptors. | Smith, AJ., et al. 2004. J Pharmacol Exp Ther. 311: 601-9. PMID: 15210837
- In vitro and in vivo inhibitory effect of stiripentol on clobazam metabolism. | Giraud, C., et al. 2006. Drug Metab Dispos. 34: 608-11. PMID: 16415114
- Identification of structures within GABAA receptor alpha subunits that regulate the agonist action of pentobarbital. | Drafts, BC. and Fisher, JL. 2006. J Pharmacol Exp Ther. 318: 1094-101. PMID: 16728592
- The anti-convulsant stiripentol acts directly on the GABA(A) receptor as a positive allosteric modulator. | Fisher, JL. 2009. Neuropharmacology. 56: 190-7. PMID: 18585399
- Interactions between modulators of the GABA(A) receptor: Stiripentol and benzodiazepines. | Fisher, JL. 2011. Eur J Pharmacol. 654: 160-5. PMID: 21237147
- The effects of stiripentol on GABA(A) receptors. | Fisher, JL. 2011. Epilepsia. 52 Suppl 2: 76-8. PMID: 21463286
- Design and synthesis of novel stiripentol analogues as potential anticonvulsants. | Aboul-Enein, MN., et al. 2012. Eur J Med Chem. 47: 360-9. PMID: 22118828
- Efficacy of stiripentol in hyperthermia-induced seizures in a mouse model of Dravet syndrome. | Cao, D., et al. 2012. Epilepsia. 53: 1140-5. PMID: 22578034
- Neuroprotective activity of stiripentol with a possible involvement of voltage-dependent calcium and sodium channels. | Verleye, M., et al. 2016. J Neurosci Res. 94: 179-89. PMID: 26511438
- Stiripentol efficacy and safety in Dravet syndrome: a 12-year observational study. | Myers, KA., et al. 2018. Dev Med Child Neurol. 60: 574-578. PMID: 29473155
- Stiripentol add-on therapy for focal refractory epilepsy. | Brigo, F., et al. 2018. Cochrane Database Syst Rev. 5: CD009887. PMID: 29747241
- Stiripentol protects against calcium oxalate nephrolithiasis and ethylene glycol poisoning. | Le Dudal, M., et al. 2019. J Clin Invest. 129: 2571-2577. PMID: 30946030
- Stiripentol for the treatment of seizures in Dravet syndrome. | Eschbach, K. and Knupp, KG. 2019. Expert Rev Clin Pharmacol. 12: 379-388. PMID: 31017478
- Stiripentol identifies a therapeutic target to reduce oxaluria. | Letavernier, E. and Daudon, M. 2020. Curr Opin Nephrol Hypertens. 29: 394-399. PMID: 32452916
- Antiepileptic Stiripentol May Influence Bones. | Matuszewska, A., et al. 2021. Int J Mol Sci. 22: PMID: 34281215
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Stiripentol, 100 mg | sc-208402 | 100 mg | $388.00 |