Molecular structure of Stigmasterol, CAS Number: 83-48-7
Stigmasterol (CAS 83-48-7)
See product citations (7)
Alternate Names:
Stigmasta-5,22-dien-3-ol; 3β-Hydroxy-24-ethyl-5,22-cholestadiene; 5,22-Stigmastadien-3β-ol
Application:
Stigmasterol is a phytosterol with chemical structure similar to cholesterol that exhibits anti-cancer, anti-pyretic, anti-inflammatory and immune-modulating effects
CAS Number:
83-48-7
Purity:
≥95%
Molecular Weight:
412.69
Molecular Formula:
C29H48O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Stigmasterol is a plant sterol that functions as a precursor to various hormones and signaling molecules. It acts by modulating the fluidity and permeability of cell membranes, influencing the activity of membrane-bound enzymes and transport proteins. Stigmasterol also plays a role in regulating gene expression and cell signaling pathways, impacting cellular processes such as growth, differentiation, and apoptosis. At the molecular level, it interacts with lipid bilayers and membrane proteins, affecting their conformation and activity. Stigmasterol can also interfere with cholesterol absorption and metabolism, potentially influencing lipid homeostasis and inflammatory responses. Stigmasterol may exhibit antioxidant and anti-inflammatory properties, which may contribute to its impact on cellular function and signaling.
Stigmasterol (CAS 83-48-7) References
- Stigmasterol Alleviates Cutaneous Allergic Responses in Rodents. | Antwi, AO., et al. 2018. Biomed Res Int. 2018: 3984068. PMID: 30140696
- Stigmasterol promotes neuronal migration via reelin signaling in neurosphere migration assays. | Haque, MN. and Moon, IS. 2020. Nutr Neurosci. 23: 679-687. PMID: 30433855
- Stigmasterol stimulates transintestinal cholesterol excretion independent of liver X receptor activation in the small intestine. | Lifsey, HC., et al. 2020. J Nutr Biochem. 76: 108263. PMID: 31759199
- Stigmasterol as a potential biomarker for amphotericin B resistance in Leishmania donovani. | Bansal, R., et al. 2020. J Antimicrob Chemother. 75: 942-950. PMID: 31886855
- Stigmasterol alleviates cerebral ischemia/reperfusion injury by attenuating inflammation and improving antioxidant defenses in rats. | Liang, Q., et al. 2020. Biosci Rep. 40: PMID: 32149332
- Stigmasterol protects rats from collagen induced arthritis by inhibiting proinflammatory cytokines. | Ahmad Khan, M., et al. 2020. Int Immunopharmacol. 85: 106642. PMID: 32470883
- Stigmasterol isolated from the chloroform fraction of Adenopus breviflorus Benth fruit induces mitochondrial-dependent apoptosis in rat liver. | Oyedeji, TA., et al. 2021. J Complement Integr Med. 18: 737-744. PMID: 33964200
- Stigmasterol root exudation arising from Pseudomonas inoculation of the duckweed rhizosphere enhances nitrogen removal from polluted waters. | Lu, Y., et al. 2021. Environ Pollut. 287: 117587. PMID: 34182390
- Stigmasterol can be new steroidal drug for neurological disorders: Evidence of the GABAergic mechanism via receptor modulation. | Karim, N., et al. 2021. Phytomedicine. 90: 153646. PMID: 34280827
- The Mechanism of Xiaoyao San in the Treatment of Ovarian Cancer by Network Pharmacology and the Effect of Stigmasterol on the PI3K/Akt Pathway. | Li, M., et al. 2021. Dis Markers. 2021: 4304507. PMID: 34306252
- Stigmasterol inhibits the progression of lung cancer by regulating retinoic acid-related orphan receptor C. | Dong, Y., et al. 2021. Histol Histopathol. 36: 1285-1299. PMID: 34713889
- Stigmasterol alleviates interleukin-1beta-induced chondrocyte injury by down-regulatingsterol regulatory element binding transcription factor 2 to regulateferroptosis. | Mo, Z., et al. 2021. Bioengineered. 12: 9332-9340. PMID: 34806937
- Stigmasterol attenuates inflammatory response of microglia via NF-κB and NLRP3 signaling by AMPK activation. | Jie, F., et al. 2022. Biomed Pharmacother. 153: 113317. PMID: 35772378
- Stigmasterol alleviates allergic airway inflammation and airway hyperresponsiveness in asthma mice through inhibiting substance-P receptor. | Zhang, J., et al. 2023. Pharm Biol. 61: 449-458. PMID: 36788676
- Stigmasterol isolated from Azadirachta indica flowers attenuated glutamate-induced neurotoxicity via downregulation of the Cdk5/p35/p25 signaling pathway in the HT-22 cells. | Mongkolpobsin, K., et al. 2023. Phytomedicine. 113: 154728. PMID: 36898255
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Stigmasterol, 1 g | sc-281156 | 1 g | $44.00 |