Molecular structure of STF 083010, CAS Number: 307543-71-1
STF 083010 (CAS 307543-71-1)
See product citations (3)
Alternate Names:
N-[(2-Hydroxy-1-naphthalenyl)methylene]-2-thiophenesulfonamide
Application:
STF 083010 is a potent IRE1 endonuclease inhibitor
CAS Number:
307543-71-1
Molecular Weight:
317.38
Molecular Formula:
C15H11NO3S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
STF 083010 inhibits IRE1 endonuclease activity specifically through endogenous XBP1 mRNA splicing. STF 083010 may act to induce cytotoxic and cytostatic effects in CD138+ multiple myeloma (MM) cells in vitro in addition to inhibiting bortezomib-induced XBP1 activity in myeloma xenografts in vivo. STF 083010 shows no effect against IRE1 kinase activity.
STF 083010 (CAS 307543-71-1) References
- Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma. | Papandreou, I., et al. 2011. Blood. 117: 1311-4. PMID: 21081713
- A novel chemical, STF-083010, reverses tamoxifen-related drug resistance in breast cancer by inhibiting IRE1/XBP1. | Ming, J., et al. 2015. Oncotarget. 6: 40692-703. PMID: 26517687
- Involvement of XBP1s in Blue Light-Induced A2E-Containing Retinal Pigment Epithelium Cell Death. | Lu, B., et al. 2017. Ophthalmic Res. 57: 252-262. PMID: 28099966
- IRE1α inhibition decreased TXNIP/NLRP3 inflammasome activation through miR-17-5p after neonatal hypoxic-ischemic brain injury in rats. | Chen, D., et al. 2018. J Neuroinflammation. 15: 32. PMID: 29394934
- Quercetin ameliorates HFD-induced NAFLD by promoting hepatic VLDL assembly and lipophagy via the IRE1a/XBP1s pathway. | Zhu, X., et al. 2018. Food Chem Toxicol. 114: 52-60. PMID: 29438776
- Bax inhibitor-1 protects from nonalcoholic steatohepatitis by limiting inositol-requiring enzyme 1 alpha signaling in mice. | Lebeaupin, C., et al. 2018. Hepatology. 68: 515-532. PMID: 29457838
- STF-083010, an inhibitor of XBP1 splicing, attenuates acute renal failure in rats by suppressing endoplasmic reticulum stress-induced apoptosis and inflammation. | Liu, L., et al. 2018. Exp Anim. 67: 373-382. PMID: 29695649
- Inhibition of endoplasmic-reticulum-stress-mediated autophagy enhances the effectiveness of chemotherapeutics on pancreatic cancer. | Thakur, PC., et al. 2018. J Transl Med. 16: 190. PMID: 29986726
- Inositol-Requiring Enzyme 1 Alpha Endoribonuclease Specific Inhibitor STF-083010 Alleviates Carbon Tetrachloride Induced Liver Injury and Liver Fibrosis in Mice. | Chen, QQ., et al. 2018. Front Pharmacol. 9: 1344. PMID: 30538632
- Sirtuin-1 ameliorates cadmium-induced endoplasmic reticulum stress and pyroptosis through XBP-1s deacetylation in human renal tubular epithelial cells. | Chou, X., et al. 2019. Arch Toxicol. 93: 965-986. PMID: 30796460
- Inositol-requiring enzyme 1 alpha endoribonuclease specific inhibitor STF-083010 protects the liver from thioacetamide-induced oxidative stress, inflammation and injury by triggering hepatocyte autophagy. | Zhan, F., et al. 2019. Int Immunopharmacol. 73: 261-269. PMID: 31121416
- Mechanism of inositol-requiring enzyme 1-alpha inhibition in endoplasmic reticulum stress and apoptosis in ovarian cancer cells. | Barez, SR., et al. 2020. J Cell Commun Signal. 14: 403-415. PMID: 32200504
- Endoplasmic reticulum stress related factor IRE1α regulates TXNIP/NLRP3-mediated pyroptosis in diabetic nephropathy. | Ke, R., et al. 2020. Exp Cell Res. 396: 112293. PMID: 32950473
- Porcine epidemic diarrhea virus infections induce autophagy in Vero cells via ROS-dependent endoplasmic reticulum stress through PERK and IRE1 pathways. | Sun, P., et al. 2021. Vet Microbiol. 253: 108959. PMID: 33360915
- Genetic and pharmacological inhibition of XBP1 protects against APAP hepatotoxicity through the activation of autophagy. | Ye, H., et al. 2022. Cell Death Dis. 13: 143. PMID: 35145060
Inhibitor of:
ATF-6α, C1orf122, chaperonin containing TCP1 ring complex (CCT), ERdj4, Ero1-Lβ, HERPUD2, IRE1, IRE1α, IRE1β, NMNAT-1, reticulocalbin-1, SLITRK1, TRAM2, and XBP-1.Activator of:
Ninein, and UBA2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
STF 083010, 5 mg | sc-474562 | 5 mg | $127.00 | |||
STF 083010, 10 mg | sc-474562A | 10 mg | $180.00 | |||
STF 083010, 50 mg | sc-474562B | 50 mg | $400.00 | |||
STF 083010, 100 mg | sc-474562C | 100 mg | $700.00 | |||
STF 083010, 200 mg | sc-474562D | 200 mg | $1212.00 |