Stem-Cell Factor/c-Kit Inhibitor, ISCK03 (CAS 945526-43-2)

Stem-Cell Factor/c-Kit Inhibitor, ISCK03, is a small molecule chemical primarily recognized for its targeted inhibition of the c-Kit receptor tyrosine kinase. This specific action disrupts the signaling pathways crucial for the growth and survival of certain cell types, particularly those involved in early stem cell and progenitor cell development. ISCK03 has been pivotal in studying the c-Kit signaling mechanism under controlled laboratory conditions. By blocking the c-Kit receptor, ISCK03 serves as a tool to explain the roles of this kinase in cellular processes such as proliferation, differentiation, and apoptosis in various cell types. This is particularly significant in hematopoiesis and melanogenesis, where c-Kit plays a crucial role. The ability of ISCK03 to specifically inhibit c-Kit has also made it valuable in stem cell research. It is used to investigate the maintenance and function of stem cells in various tissues, providing insights into the cellular mechanisms that could potentially influence stem cell behavior and lineage specification. Moreover, in developmental biology studies, ISCK03 helps in understanding how interruptions in c-Kit signaling can affect organogenesis and tissue repair mechanisms. Furthermore, the inhibitor′s role extends to its utility in molecular biology and biochemistry research settings, where it is employed to dissect the biochemical pathways mediated by c-Kit. This includes studying the downstream effects of c-Kit inhibition on cellular signaling cascades, such as those involving PI3K/AKT and MAPK, which are vital for cell cycle regulation and survival signals.