STC1 Antibody (1A3): sc-293435

STC1 Antibody (1A3) is a mouse monoclonal IgG2a kappa light chain antibody that detects STC1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-STC1 antibody (1A3) is available as the non-conjugated format. Stanniocalcin 1 (STC1) is a crucial peptide hormone that plays a significant role in calcium and phosphate homeostasis, which is vital for various physiological processes, including bone health and cellular signaling. STC1 is primarily secreted by the kidneys and has been shown to exert anti-hypercalcemic effects, counteracting elevated calcium levels in the bloodstream. Notably, STC1 is phosphorylated in vitro by protein kinase C, which may influence activity and interactions with other proteins. In addition to calcium regulation roles, STC1 has been implicated in various pathological conditions, including adrenal tumors, where STC1 is co-expressed with STC2, which has opposing effects on calcium levels. STC1 presence in human adrenal tumors, such as pheochromocytoma and differentiated neuroblastoma, highlights potential as a biomarker for these conditions. STC1 (1A3) antibody is an essential tool for studying the intricate roles of STC1 in health and disease.

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STC1 Antibody (1A3) References:

1. Regulation by 1alpha,25-dihydroxyvitamin D(3) of expression of stanniocalcin messages in the rat kidney and ovary.  |  Honda, S., et al. 1999. FEBS Lett. 459: 119-22. PMID: 10508929
2. Expression of stanniocalcin in zona glomerulosa and medulla of normal human adrenal glands, and some adrenal tumors and cell lines.  |  Miura, W., et al. 2000. APMIS. 108: 367-72. PMID: 10937775
3. Stanniocalcin 1 and 2 are secreted as phosphoproteins from human fibrosarcoma cells.  |  Jellinek, DA., et al. 2000. Biochem J. 350 Pt 2: 453-61. PMID: 10947959
4. Stanniocalcin gene expression during mouse urogenital development: a possible role in mesenchymal-epithelial signalling.  |  Stasko, SE. and Wagner, GF. 2001. Dev Dyn. 220: 49-59. PMID: 11146507
5. STC1 and NF-κB p65 (Rel A) is Constitutively Activated in Colorectal Cancer.  |  Rezapour, S., et al. 2016. Clin Lab. 62: 463-9. PMID: 27156337
6. Oncogenic AURKA-enhanced N6-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells.  |  Peng, F., et al. 2021. Cell Res. 31: 345-361. PMID: 32859993
7. Epithelial expression and role of secreted STC1 on asthma airway hyperresponsiveness through calcium channel modulation.  |  Xu, J., et al. 2021. Allergy. 76: 2475-2487. PMID: 33378582
8. STAT3 induces breast cancer growth via ANGPTL4, MMP13 and STC1 secretion by cancer associated fibroblasts.  |  Avalle, L., et al. 2022. Oncogene. 41: 1456-1467. PMID: 35042959
9. Cancer-associated mesothelial cell-derived ANGPTL4 and STC1 promote the early steps of ovarian cancer metastasis.  |  Bajwa, P., et al. 2023. JCI Insight. 8: PMID: 36795484
10. The stromal-tumor amplifying STC1-Notch1 feedforward signal promotes the stemness of hepatocellular carcinoma.  |  Bai, S., et al. 2023. J Transl Med. 21: 236. PMID: 37004088
11. STC1 competitively binding βPIX enhances melanoma progression via YAP nuclear translocation and M2 macrophage recruitment through the YAP/CCL2/VEGFA/AKT feedback loop.  |  Ren, Z., et al. 2024. Pharmacol Res. 204: 107218. PMID: 38768671
12. Identification of a second stanniocalcin cDNA in mouse and human: stanniocalcin 2.  |  Chang, AC. and Reddel, RR. 1998. Mol Cell Endocrinol. 141: 95-9. PMID: 9723890

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-STC1 Antibody (1A3) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-STC1 Antibody (1A3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

STC1 Antibody (1A3) Specifications

Alternate Product Name: Stanniocalcin 1

Product Clone Name: 1A3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 141-247

Epitope Target: STC1

Epitope Species: human

Product Reactivity/Detection: STC1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for STC1 Antibody (1A3): N/A