Molecular structure of Stauprimide, CAS Number: 154589-96-5
Stauprimide (CAS 154589-96-5)
Alternate Names:
N-Benzoyl-7-oxostaurosporine
Application:
Stauprimide is an indolocarbazole promoter of embryonic stem cell differentiation
CAS Number:
154589-96-5
Purity:
>95%
Molecular Weight:
584.6
Molecular Formula:
C35H28N4O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Stauprimide is an indolocarbazole semi-synthetic small molecule shown to significantly increase the efficiency of directed embryonic stem cell differentiation. Stauprimide inhibits the nuclear localization of NME2, blocking and downregulating c-Myc expression. The expression of c-Myc is for embryonic stem cell self-renewal, and intervention by Stauprimide allows for more efficient lineage-specific differentiation. NME2 is also indicated to be upregulated in certain cancers, indicating further application for the blocking action of Stauprimide.
Stauprimide (CAS 154589-96-5) References
- Using small molecules to great effect in stem cell differentiation. | Zaret, KS. 2009. Cell Stem Cell. 4: 373-4. PMID: 19427285
- A small molecule primes embryonic stem cells for differentiation. | Zhu, S., et al. 2009. Cell Stem Cell. 4: 416-26. PMID: 19427291
- Small molecules in cellular reprogramming and differentiation. | Yuan, X., et al. 2011. Prog Drug Res. 67: 253-66. PMID: 21141734
- Treatment of human embryonic stem cells with different combinations of priming and inducing factors toward definitive endoderm. | Tahamtani, Y., et al. 2013. Stem Cells Dev. 22: 1419-32. PMID: 23249309
- Stauprimide Priming of Human Embryonic Stem Cells toward Definitive Endoderm. | Tahamtani, Y., et al. 2014. Cell J. 16: 63-72. PMID: 24518969
- Staurosporine analogs promote distinct patterns of process outgrowth and polyploidy in small cell lung carcinoma cells. | Gallala, H., et al. 2015. Tumour Biol. 36: 2725-35. PMID: 25487614
- Target identification for biologically active small molecules using chemical biology approaches. | Lee, H. and Lee, JW. 2016. Arch Pharm Res. 39: 1193-201. PMID: 27387321
- Small molecule selectively suppresses MYC transcription in cancer cells. | Bouvard, C., et al. 2017. Proc Natl Acad Sci U S A. 114: 3497-3502. PMID: 28292893
- The synthetic molecule stauprimide impairs cell growth and migration in triple-negative breast cancer. | Carrillo, P., et al. 2023. Biomed Pharmacother. 158: 114070. PMID: 36526536
- Stauprimide suppresses proliferation and survival via inhibition of IRF4 expression and activation of JNK in multiple myeloma cells | Kiyohara, K. and Ito, S. 2022. Journal of Iwate Medical Assiociation. 74(3): 95-106.
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OTUD6B.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Stauprimide, 500 µg | sc-202346 | 500 µg | $53.00 |