Statine (CAS 49642-07-1)
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Statine is a chemical compound that functions as a competitive inhibitor of the enzyme HMG-CoA reductase. It plays a role in blocking the conversion of HMG-CoA to mevalonate, a key step in the biosynthesis of cholesterol. By inhibiting this enzyme, statine disrupts the production of cholesterol in cells, ultimately leading to a decrease in cholesterol levels. Statine targets the active site of HMG-CoA reductase, preventing the enzyme from carrying out its catalytic function. As a result, statine interferes with the normal cellular processes involved in cholesterol synthesis. This mode of action at the molecular level makes statine a useful substance for studying the regulation of cholesterol metabolism and its potential impact on cellular function.
Statine (CAS 49642-07-1) References
- An Improved Enantiospecific Synthesis of Statine and Statine Analogs via 4-(N,N-Dibenzylamino)-3-keto Esters. | Hoffman, RV. and Tao, J. 1997. J Org Chem. 62: 2292-2297. PMID: 11671547
- Design of rat renin inhibitory peptides. | Hui, KY., et al. 1988. J Med Chem. 31: 1679-86. PMID: 3045320
- Inhibition of cathepsin D by substrate analogues containing statine and by analogues of pepstatin. | Agarwal, NS. and Rich, DH. 1986. J Med Chem. 29: 2519-24. PMID: 3783611
- Synthesis of all the stereoisomers of statine (4-amino-3-hydroxy-6-methylheptanoic acid). Inhibition of pepsin activity by N-carbobenzoxy-L-valyl-L-valyl-statine derived from the four stereoisomers. | Liu, WS., et al. 1979. J Med Chem. 22: 577-9. PMID: 379333
- Pepstatin-derived inhibitors of aspartic proteinases. A close look at an apparent transition-state analogue inhibitor. | Rich, DH. 1985. J Med Chem. 28: 263-73. PMID: 3882966
- Renin inhibitors. Syntheses of subnanomolar, competitive, transition-state analogue inhibitors containing a novel analogue of statine. | Boger, J., et al. 1985. J Med Chem. 28: 1779-90. PMID: 3906131
- Novel renin inhibitors containing the amino acid statine. | Boger, J., et al. Nature. 303: 81-4. PMID: 6341856
- The Stereoselective Synthesis of threo-3-Hydroxy-4-amino Acids | Katsuki, T., & Yamaguchi, M. 1976. Bulletin of the Chemical Society of Japan. 49(11): 3287-3290.
- Synthesis of 4-amino-3-hydroxy-6-methylheptanoic acid by a modified Reformatsky reaction | Liu, W. S., & Glover, G. I. 1978. The Journal of Organic Chemistry. 43(4): 754-755.
- A short and efficient synthesis of (3S,4S)-4-[(tert-Butyloxycarbonyl)amino]-5-cyclohexyl-3-hydroxypentanoic acid ethyl ester | Schuda, P. F., Greenlee, W. J., Chakravarty, P. K., & Eskola, P. 1988. The Journal of Organic Chemistry. 53(4): 873-875.
- Highly stereocontrolled synthesis of the four individual stereoisomers of statine | Kano, S., Yuasa, Y., Yokomatsu, T., & Shibuya, S. 1988. The Journal of Organic Chemistry. 53(16): 3865-3868.
- Enantioselective and diastereoselective formation of syn-3-hydroxy-4-amino acids (syn-statines) via tetramic acids | Schmidt, U., Riedl, B., Haas, G., Griesser, H., Vetter, A., & Weinbrenner, S. 1993. Synthesis. 1993(02): 216-220.
- A facile synthesis of N-protected statine and analogs via a lipase-catalyzed kinetic resolution | Baenziger, M., McGarrity, J. F., & Meul, T. 1993. The Journal of Organic Chemistry. 58(15): 4010-4012.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Statine, 50 mg | sc-296421 | 50 mg | $291.00 | |||
Statine, 250 mg | sc-296421A | 250 mg | $1170.00 |