Stat6 Antibody (8C12): sc-81539
- Stat6 Antibody (8C12) is a mouse monoclonal IgG1 provided at 50 µg/0.5 ml
- raised against a synthetic peptide corresponding to amino acids 650-670 of Stat6 of human origin
- recommended for detection of Stat6 of human and canine origin by WB, IP and IF
- See Stat6 (D-1): sc-374021 for Stat6 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Stat6 Antibody (8C12). This work is in progress.
Stat6 Antibody (8C12) is a mouse monoclonal IgG1 antibody that detects Stat6 in human and canine samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Stat6 plays a crucial role in mediating the effects of interleukin-4 (IL-4) and interleukin-13 (IL-13), which are key cytokines involved in the immune response and regulation of inflammation. Upon activation by these cytokines, Stat6 undergoes phosphorylation, leading to dimerization and subsequent translocation to the nucleus, where Stat6 regulates the expression of genes associated with Th2 cell differentiation and allergic responses. The significance of Stat6 in these processes highlights potential therapeutic applications in conditions such as asthma and other allergic diseases. Anti-Stat6 antibody (8C12) provides reliable detection and characterization of Stat6, facilitating research into immune signaling pathways and disease mechanisms.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Stat6 Antibody (8C12) References:
- Signaling mechanisms, interaction partners, and target genes of STAT6. | Hebenstreit, D., et al. 2006. Cytokine Growth Factor Rev. 17: 173-88. PMID: 16540365
- Activation of STAT6 by STING is critical for antiviral innate immunity. | Chen, H., et al. 2011. Cell. 147: 436-46. PMID: 22000020
- STAT6 Expression in Solitary Fibrous Tumor and Histologic Mimics: a Single Institution Experience. | Saeed, O., et al. 2020. Appl Immunohistochem Mol Morphol. 28: 311-315. PMID: 30664532
- STAT6 mediates the effect of ethanol on neuroinflammatory response in TBI. | Olde Heuvel, F., et al. 2019. Brain Behav Immun. 81: 228-246. PMID: 31207335
- NAB2-STAT6 fusion protein mediates cell proliferation and oncogenic progression via EGR-1 regulation. | Park, YS., et al. 2020. Biochem Biophys Res Commun. 526: 287-292. PMID: 32216968
- STAT6 Pathway Is Critical for the Induction and Function of Regulatory T Cells Induced by Mucosal B Cells. | Chu, KH., et al. 2020. Front Immunol. 11: 615868. PMID: 33584704
- STAT6-Dependent Exacerbation of House Dust Mite-Induced Allergic Airway Disease in Mice by Multi-Walled Carbon Nanotubes. | Ihrie, MD., et al. 2021. NanoImpact. 22: PMID: 33860111
- STAT6 Is Critical for the Induction of Regulatory T Cells In Vivo Controlling the Initial Steps of Colitis-Associated Cancer. | Delgado-Ramirez, Y., et al. 2021. Int J Mol Sci. 22: PMID: 33919941
- [STAT6 positive dedifferentiated liposarcoma: a clinicopathological analysis of two cases]. | Du, YY., et al. 2022. Zhonghua Bing Li Xue Za Zhi. 51: 761-763. PMID: 35922170
- STAT6-targeting antisense oligonucleotides against solitary fibrous tumor. | Li, Y., et al. 2024. Mol Ther Nucleic Acids. 35: 102154. PMID: 38511173
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Stat6 Antibody (8C12) | sc-81539 | 50 µg/0.5 ml | $322.00 |