Molecular structure of Stat5 Inhibitor, CAS Number: 285986-31-4
Stat5 Inhibitor (CAS 285986-31-4)
See product citations (36)
Alternate Names:
Stat5 Inhibitor is known as a nonpetidic nicotinoyl hydrazone.
Application:
Stat5 Inhibitor is a cell-permeable compound that selectively targets the SH2 domain of Stat5 (IC50 = 47 µM against STAT5b SH2 domain EPO peptide binding activity).
CAS Number:
285986-31-4
Purity:
≥97%
Molecular Weight:
293.28
Molecular Formula:
C16H11N3O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Stat5 Inhibitor is a cell permeable nonpetidic nicotinoyl hydrazone which suppresses STAT5 via binding to the SH2 domain. Studies indicate that Stat5 Inhibitor suppresses the SH2 domain of STAT1 and STAT3 to a lesser extent than STAT5 inhibition. In addition, STAT5/STAT5 DNA binding in K562 nuclear extracts are inhibited by Stat5 Inhibitor. STAT5 functions biologically in various processes such as homeostasis of hematopoietic stem cells, development of blood cells, growth hormone effects, and differentiation of mammary epithelium. Stat5 Inhibitor is shown to block STAT5/STAT5 DNA binding activity in K562 nuclear extract and inhibit IFN-α-stimulated STAT5, but not STAT1 or STAT3, tyrosine phosphorylation in Daudi cells.
Stat5 Inhibitor (CAS 285986-31-4) References
- Discovery of chromone-based inhibitors of the transcription factor STAT5. | Müller, J., et al. 2008. Chembiochem. 9: 723-7. PMID: 18247434
- STAT5 polarization promotes iTregs and suppresses human T-cell alloresponses while preserving CTL capacity. | Betts, BC., et al. 2014. J Leukoc Biol. 95: 205-13. PMID: 24068731
- Energy-sensitive regulation of Na+/K+-ATPase by Janus kinase 2. | Bhavsar, SK., et al. 2014. Am J Physiol Cell Physiol. 306: C374-84. PMID: 24304834
- Histone H1 and Chromosomal Protein HMGN2 Regulate Prolactin-induced STAT5 Transcription Factor Recruitment and Function in Breast Cancer Cells. | Schauwecker, SM., et al. 2017. J Biol Chem. 292: 2237-2254. PMID: 28035005
- Interleukin-7 Induces Osteoclast Formation via STAT5, Independent of Receptor Activator of NF-kappaB Ligand. | Kim, JH., et al. 2017. Front Immunol. 8: 1376. PMID: 29104576
- Growth hormone controls lipolysis by regulation of FSP27 expression. | Sharma, R., et al. 2018. J Endocrinol. 239: 289-301. PMID: 30400015
- Magnetic resonance imaging: present status and future perspectives. | Bydder, GM. 1988. Br J Radiol. 61: 889-97. PMID: 3056559
- Akt and STAT5 mediate naïve human CD4+ T-cell early metabolic response to TCR stimulation. | Jones, N., et al. 2019. Nat Commun. 10: 2042. PMID: 31053703
- Kidney-secreted erythropoietin lowers lipidemia via activating JAK2-STAT5 signaling in adipose tissue. | Li, J., et al. 2019. EBioMedicine. 50: 317-328. PMID: 31740386
- Anti-CCL22 increases regulatory T cells in CD4+ T cells of rheumatoid arthritis patients via STAT5 pathway. | Wang, L., et al. 2020. Exp Ther Med. 19: 2127-2132. PMID: 32104275
- Prolactin-Responsive Circular RNA circHIPK3 Promotes Proliferation of Mammary Epithelial Cells from Dairy Cow. | Liu, J., et al. 2020. Genes (Basel). 11: PMID: 32245109
- CCL11 increases the proportion of CD4+CD25+Foxp3+ Treg cells and the production of IL‑2 and TGF‑β by CD4+ T cells via the STAT5 signaling pathway. | Wang, R. and Huang, K. 2020. Mol Med Rep. 21: 2522-2532. PMID: 32323817
- CCL26 regulates the proportion of CD4+CD25+FOXP3+ Tregs and the production of inflammatory factors in peripheral blood mononuclear cells following acute ischemic stroke via the STAT5 pathway. | Dong, Z., et al. 2020. Exp Ther Med. 20: 3343-3351. PMID: 32855707
- Polyphenol containing Sargassum horneri attenuated Th2 differentiation in splenocytes of ovalbumin-sensitised mice: involvement of the transcription factors GATA3/STAT5/NLRP3 in Th2 polarization. | Herath, KHINM., et al. 2021. Pharm Biol. 59: 1464-1472. PMID: 34726583
- Mutation of Signal Transducer and Activator of Transcription 5 (STAT5) Binding Sites Decreases Milk Allergen αS1-Casein Content in Goat Mammary Epithelial Cells. | Song, N., et al. 2022. Foods. 11: PMID: 35159497
Inhibitor of:
GARNL1, Rho GDI, Stat5b, and Transcription Factor.Activator of:
IκB-γ.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Stat5 Inhibitor, 10 mg | sc-355979 | 10 mg | $208.00 | |||
Stat5 Inhibitor, 100 mg | sc-355979A | 100 mg | $1532.00 |